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Exploratory research of atherosclerosis risk by HDL function evaluation and haptoglobin typing

Research Project

Project/Area Number 26461116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionJikei University School of Medicine

Principal Investigator

Yoshida Hiroshi  東京慈恵会医科大学, 医学部, 教授 (30333529)

Research Collaborator SHIMIZU Tomo  
MIYAZAKI Osamu  
HIRAISHI Chika  
SATO Ryo  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords動脈硬化 / HDL / コレステロール引き抜き能 / 安定同位体 / HDL / コレステロール逆転送系 / コレステロール / マクロファージ / デキストリン / コレステロール引く抜き能 / アクセプターの最適化 / アスタキサンチン / HDLコレステロール / 機能評価
Outline of Final Research Achievements

To establish cholesterol efflux capacity (CEC) method with stable isotope-labeled cholesterol, a fundamental method to progress this study project, was viewed as a critical issue to be addressed. The incidence of cardiovascular events is inversely correlated, to a greater extent, with cholesterol efflux capacity (CEC) than with HDL-cholesterol level. Here we established a CEC measurement technique using stable isotope-labeled cholesterol as an alternative to conventional radioisotope (RI)-labeled cholesterol. Our established stable-isotope method will facilitate CEC measurement in clinical laboratories.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2018 2017 2016 2015 2014

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Invited: 9 results) Book (1 results)

  • [Journal Article] Effect of angiotensin II on matrix metalloproteinase-2 secretion in human umbilical vein endothelial cells.2018

    • Author(s)
      Sato R, Hiraishi C, Yoshida H.
    • Journal Title

      J Cardiovasc Pharmacology

      Volume: 71 Issue: 4 Pages: 233-239

    • DOI

      10.1097/fjc.0000000000000564

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age and sex differences in serum adiponectin and its association with lipoprotein fractions.2018

    • Author(s)
      Tomono Y, Hiraishi C, Yoshida H.
    • Journal Title

      Ann Clin Biochem

      Volume: 55 Issue: 1 Pages: 165-171

    • DOI

      10.1177/0004563217699233

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholesterol Levels of Six Fractionated Serum Lipoproteins and its Relevance to Coronary Heart Disease Risk Scores2017

    • Author(s)
      Manita D, Yoshida H, Hirowatari Y.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 9 Pages: 928-939

    • DOI

      10.5551/jat.34728

    • NAID

      130006038522

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Determination of Fasting and Non-Fasting Cholesterol Levels of Low- and High-Density Lipoproteins with Homogenous Assays: A Promising Reliable Way to Assessment of Dyslipidemia2017

    • Author(s)
      Yoshida H
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 6 Pages: 569-571

    • DOI

      10.5551/jat.ED076

    • NAID

      130005687829

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A First-in-Class Drug, Lomitapide, Tailored to Patients with Homozygous Familial Hypercholesterolemia is Just about Meeting with Good News to Them2017

    • Author(s)
      Yoshida H
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 4 Pages: 390-392

    • DOI

      10.5551/jat.ED069

    • NAID

      130005529931

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monthly PCSK9 inhibitors: The CHOICE for prolonged duration of effect.2016

    • Author(s)
      de Carvalho LS, Yoshida H
    • Journal Title

      Atherosclerosis

      Volume: 254 Pages: 300-302

    • DOI

      10.1016/j.atherosclerosis.2016.09.013

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Understanding of Diabetic Dyslipidemia by Using the Anion-Exchange High Performance Liquid Chromatography Data.2016

    • Author(s)
      Yanai H, Hirowatari Y, Ito K, Kurosawa H, Tada N, Yoshida H.
    • Journal Title

      J Clin Med Res

      Volume: 8 Issue: 5 Pages: 424-426

    • DOI

      10.14740/jocmr2533w

    • Related Report
      2016 Research-status Report
    • Open Access
  • [Journal Article] Potential Anti-Atherosclerotic Properties of Astaxanthin2016

    • Author(s)
      Kishimoto Y, Yoshida H, Kondo K.
    • Journal Title

      Marine Drugs

      Volume: 14 Issue: 2 Pages: 35-35

    • DOI

      10.3390/md14020035

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A rapid anion-exchange chromatography for measurement of cholesterol concentrations in five lipoprotein classes and estimation of lipoprotein profiles in male volunteers without overt diseases2015

    • Author(s)
      Manita D, Hirowatari Y, Yoshida H
    • Journal Title

      Ann Clin Biochem

      Volume: 52 Issue: 6 Pages: 638-46

    • DOI

      10.1177/0004563215584405

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of pitavastatin on glucose, HbA1c and incident diabetes: A meta-analysis of randomized controlled clinical trials in individuals without diabetes2015

    • Author(s)
      Vallejo-Vaz AJ, Kondapally Seshasai SR, Kurogi K, Michishita I, Nozue T, Sugiyama S, Tsimikas S, Yoshida H, Ray KK
    • Journal Title

      Atherosclerosis

      Volume: 241 Issue: 2 Pages: 409-18

    • DOI

      10.1016/j.atherosclerosis.2015.06.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] イオン交換クロマトグラフィーによるリポ蛋白分析システムの基礎的評価および臨床的有用性2015

    • Author(s)
      佐藤亮、阿部美佐子、齊藤正二、小池優、真仁田大輔、廣渡祐史、吉田博
    • Journal Title

      臨床病理

      Volume: 63 Pages: 1023-8

    • NAID

      40020622149

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical relevance of decreased ratios of serum eicosapentaenoic acid/arachidonic acid (AA) and docosahexaenoic acid/AA to impaired arterial stiffness2014

    • Author(s)
      Yoshida H, Ito K, Sato R, Kurosawa H, Tomono Y, Hirowatari Y, Shimizu M, Tada N.
    • Journal Title

      Int J Cardiol

      Volume: 177 Issue: 2 Pages: 517-519

    • DOI

      10.1016/j.ijcard.2014.08.093

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 残余リスクとしての高トリグリセライド血症とn-3系多価不飽和脂肪酸の役割2017

    • Author(s)
      吉田 博
    • Organizer
      第81回日本循環器学会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 会長講演 健康長寿と歩む機能性食品~脂質異常症と動脈硬化の視座から~.2017

    • Author(s)
      吉田 博
    • Organizer
      第15回日本機能性食品医用学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プロジェクト報告.安定同位体を用いたコレステロール引き抜き能評価系の検討.2017

    • Author(s)
      宮崎 修、清水 知、佐藤 亮、吉田 博.
    • Organizer
      第57回日本臨床化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Update5.血清脂質検査に関する最新の話題.2017

    • Author(s)
      吉田 博
    • Organizer
      第27回臨床内分泌代謝Update
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 健常者におけるリポ蛋白中ビタミンE類の評価および動脈硬化リスクファクターとの関連性.2017

    • Author(s)
      廣渡祐史、真仁田大輔、吉田 博.
    • Organizer
      第49回日本動脈硬化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂質異常症検査の活用法~高トリグリセライド血症の検査手順~2016

    • Author(s)
      吉田 博
    • Organizer
      第63回日本臨床検査医学会
    • Place of Presentation
      神戸
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 食事療法における脂質のエビデンス2016

    • Author(s)
      吉田 博
    • Organizer
      第59回日本糖尿病学会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 残存リスクを考慮したハイリスク高コレステロール血症患者の治療戦略2016

    • Author(s)
      吉田 博
    • Organizer
      第59回日本糖尿病学会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 脂質栄養と脂質異常症2016

    • Author(s)
      吉田 博
    • Organizer
      第70回日本栄養食糧学会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-14
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] コレステロール摂取量制限と脂肪酸の質と量2016

    • Author(s)
      吉田博
    • Organizer
      第19回日本病態栄養学
    • Place of Presentation
      横浜
    • Year and Date
      2016-01-10
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 脂質異常症の発症ならびに重症化予防のための食事のあり方2015

    • Author(s)
      吉田博
    • Organizer
      第37回日本臨床栄養学会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] アスタキサンチンの心血管病リスク低減への期待 ~ストレスと向き合う栄養物質~2015

    • Author(s)
      吉田博
    • Organizer
      第17回日本災害看護学会
    • Place of Presentation
      仙台
    • Year and Date
      2015-08-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 研修医・医学生のための症例で学ぶ栄養学2017

    • Author(s)
      吉田 博
    • Total Pages
      185
    • Publisher
      建帛社
    • Related Report
      2016 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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