| Project/Area Number |
26461116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Research Collaborator |
SHIMIZU Tomo
MIYAZAKI Osamu
HIRAISHI Chika
SATO Ryo
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 動脈硬化 / HDL / コレステロール引き抜き能 / 安定同位体 / ＨＤＬ / コレステロール逆転送系 / コレステロール / マクロファージ / デキストリン / コレステロール引く抜き能 / アクセプターの最適化 / アスタキサンチン / ＨＤＬコレステロール / 機能評価 |
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| Outline of Final Research Achievements |
To establish cholesterol efflux capacity (CEC) method with stable isotope-labeled cholesterol, a fundamental method to progress this study project, was viewed as a critical issue to be addressed. The incidence of cardiovascular events is inversely correlated, to a greater extent, with cholesterol efflux capacity (CEC) than with HDL-cholesterol level. Here we established a CEC measurement technique using stable isotope-labeled cholesterol as an alternative to conventional radioisotope (RI)-labeled cholesterol. Our established stable-isotope method will facilitate CEC measurement in clinical laboratories.
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