The role of HMGB1 in regulating mitochondrial dysfunction induced by aging

• Project/Area Number: 26461122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Yamagata University
• Principal Investigator: KUBOTA Isao 山形大学, 学内共同利用施設等, 理事 (30161673)
• Co-Investigator(Kenkyū-buntansha): 宍戸 哲郎 山形大学, 医学部, 助教 (60400545)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 糖尿病 / 脂質異常症 / 老化 / 加齢 / 心不全 / 心筋細胞 / HMGB1 / DNA障害 / ＳＭＰ３０ / 虚血再灌流

Outline of Final Research Achievements

It is well documented that reperfusion by PCI is the most effective therapy for acute myocardial infarction. Although several factors including aging and metabolic disorders is known to be associated with their prognosis, precise mechanism has not been clearly determined. We found that agingn and metabolic disorder lowered expression levels of SMP30, and ischemia/reperfusion injury was worsened at the resullt of decreased expression of SMP30. Moreover preseavation of SMP30 expression attenuated ischemia/reperfusion injury.

Research Products

• [Int'l Joint Research] MD Anderson Cancer Center(米国)
• [Int'l Joint Research] University of Texas/MD Anderson Cancer Center(米国)
• [Int'l Joint Research] Department of Cardiology/University of Texas/MD Anderson Cancer Center(米国)
• [Int'l Joint Research] Department of Pharmacology/College of Medicine/Yeungnam University(韓国)
• [Journal Article] Combined assessment of myocardial damage and electrical disturbance in chronic heart failure. (2017)
  • Author(s): Kadowaki S, Watanabe T, Otaki Y, Narumi T, Honda Y, Takahashi H, Arimoto T, Shishido T, Miyamoto T, Kubota I
  • Journal Title: World Journal of Cardiology． Volume: 9 Issue: 5 Pages: 457-465
  • DOI: 10.4330/wjc.v9.i5.457
  • Peer Reviewed
• [Journal Article] The Neutrophil-to-Lymphocyte Ratio Predicts All-Cause Mortality in Patients with Implantable Cardioverter Defibrillators. (2017)
  • Author(s): Hashimoto N, Arimoto T, Narumi T, Iwayama T, Kutsuzawa D, Ishigaki D, Kumagai YU, Tamura H, Nishiyama S, Takahashi H, Shishido T, Miyamoto T, Watanabe T, Kubota I.
  • Journal Title: Pacing Clin Electrophysiol. Volume: 40 Issue: 2 Pages: 135-144
  • DOI: 10.1111/pace.13003
  • Peer Reviewed
• [Journal Article] The impact of non-alcoholic fatty liver disease fibrosis score on cardiac prognosis in patients with chronic heart failure. (2017)
  • Author(s): Takahashi T, Watanabe T, Shishido T, Watanabe K, Sugai T, Toshima T, Kinoshita D, Yokoyama M, Tamura H, Nishiyama S, Arimoto T, Takahashi H, Yamanaka T, Miyamoto T, Kubota I.
  • Journal Title: Heart Vessels. Volume: Dec Issue: 7 Pages: 733-739
  • DOI: 10.1007/s00380-017-1113-1
• [Journal Article] Midkine Deteriorates Cardiac Remodeling via Epidermal Growth Factor Receptor Signaling in Chronic Kidney Disease. (2016)
  • Author(s): Honda Y, Shishido T, Takahashi T, Watanabe T, Netsu S, Kinoshita D, Narumi T, Kadowaki S, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Kishida S, Kadomatsu K, Takeishi Y, Kubota I.
  • Journal Title: Hypertension. Volume: 67(5) Issue: 5 Pages: 857-865
  • DOI: 10.1161/hypertensionaha.115.06922
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis (2015)
  • Author(s): Narumi T, Shishido T, Otaki Y, Kadowaki S, Honda Y, Funayama A, Honda S, Hasegawa H, Kinoshita D, Yokoyama M, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Tanaka A, Woo C, Abe J, Takeishi Y, Kubota I
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 82 Pages: 1-12
  • DOI: 10.1016/j.yjmcc.2015.02.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure. (2015)
  • Author(s): Narumi T, Watanabe T, Kadowaki S, Kinoshita D, Yokoyama M, Honda Y, Otaki Y, Nishiyama S, Takahashi H, Arimoto T, Shishido T, Miyamoto T, Kubota I
  • Journal Title: Cardiovasc Diabetol. Volume: 13 Issue: 1 Pages: 84-84
  • DOI: 10.1186/1475-2840-13-84
  • Peer Reviewed / Open Access
• [Journal Article] Electrocardiographic left ventricular hypertrophy cornell product is a feasible predictor of cardiac prognosis in patients with chronic heart failure. (2014)
  • Author(s): Otaki Y, Takahashi H, Watanabe T, Kadowaki S, Narumi T, Honda Y, Hasegawa H, Honda S, Funayama A, Nishiyama, Arimoto T, Shishido T, Miyashita T, Miyamoto T, Kubota I
  • Journal Title: Clin Res Cardiol. Volume: 103 Issue: 4 Pages: 275-284
  • DOI: 10.1007/s00392-013-0646-2
  • Peer Reviewed / Open Access
• [Journal Article] Association of renal tubular damage with cardio-renal anemia syndrome in patients with heart failure. (2014)
  • Author(s): Otaki Y, Watanabe T, Takahashi H, Narumi T, Kadowaki S, Honda Y, Arimoto T, Shishido T, Miyamoto T, Konta T, Kubota I
  • Journal Title: Int J Cardiol. Volume: 173 Issue: 2 Pages: 222-228
  • DOI: 10.1016/j.ijcard.2014.02.044
  • Peer Reviewed / Open Access
• [Presentation] Intramuscular fat deposition can predict adverse clinical outcomes in patients with peripheral artery disease． (2017)
  • Author(s): Sugai T, Takahashi H, Watanabe K, Toshima T, Takahashi T, Yokoyama M, Kinoshita D, Arimoto T, Shishido T, Miyamoto T, Watanabe T, Kubota I
  • Organizer: ESC CONGRESS 2017
  • Int'l Joint Research
• [Presentation] Myocardial damage markers can risk-stratify aortic aneurysm patients with coronary artery disease． (2017)
  • Author(s): 4)Watanabe K, Watanabe T, Yamaura G, Wanezaki M, Kutsuzawa D, Iwayama T**, Tamura H, Nishiyama S, Takahashi H, Arimoto T, Shishido T, Yamauchi S, Miyamoto T, Kubota I
  • Organizer: ESC CONGRESS 2017
  • Int'l Joint Research
• [Presentation] Impact of sarcopenia on the prognosis in heart hailure． (2017)
  • Author(s): Watanabe T, Narumi T, Isao K
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] Platelet to lymphocyte ratio is a feasible predictor for poor outcome in patients with peripheral artery disease after endovascular therapy． (2017)
  • Author(s): Yokoyama M，Watanabe T，Takahashi H，Toshima T，Otaki Y，Tamura H，Nishiyama S，Arimoto T，Shishido T，Yamauchi S，Yamanaka T，Miyamoto T，Kubota I
  • Organizer: 第49回日本動脈硬化学会総会
• [Presentation] Ｘanthine oxidoreductase plays a key role in cardio-hepatic vicious cycle in patients with heart failure． (2017)
  • Author(s): Otaki Y, Watanabe T, Yokoyama M, Kinoshita D, Nishiyama S, Takahasi H, Arimoto T, Shishido T, Miyamoto T, Kubota I
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] Cardiac nuclear High Mobility Group Box 1 in regulating cardiac remodeling (2016)
  • Author(s): 宍戸 哲郎
  • Organizer: 第33回ISHR日本部会
  • Place of Presentation: 東京コンベンションホール（東京都中央区）
  • Year and Date: 2016-12-15
  • Int'l Joint Research / Invited
• [Presentation] Regression of sokolow-lyon voltage is associated with higher incidence of cardiac events in patients with chronic heart failure. (2015)
  • Author(s): Kinoshita D, Shishido T, Takahashi T, Yokoyama M, Narumi T, Kadowaki S, Honda Y, Watanabe T, Kubota I
  • Organizer: ESC CONGRESS 2015
  • Place of Presentation: エクセル・ロンドン（イギリス・ロンドン）
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] 心筋症患者でのHigh Mobility Group Box 1 (HMGB1)発現とその意義に関する検討 (2015)
  • Author(s): 木下大資，宍戸哲郎，高橋徹也，渡邉哲，久保田功
  • Organizer: 日本心不全学会 第1回日本心筋症研究会
  • Place of Presentation: 一橋大学（東京都千代田区）
  • Year and Date: 2015-07-04
• [Presentation] Senescence marker protein 30 protect the cardiac injury from after ischemia reperfusion. (2014)
  • Author(s): Kadowaki S, Shishido T, Narumi T, Honda Y, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Takeishi Y, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: マコーミックプレイスコンベンションセンター(アメリカ合衆国シカゴ）
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Impact of fat free mass on cardiac prognosis in patients with heart failure. (2014)
  • Author(s): Narumi T, Watanabe T, Takahashi T, Yokoyama M, Kinoshita D, Kadowaki S, Honda Y, Otaki Y, Kubota I
  • Organizer: ESC CONGRESS 2014.
  • Place of Presentation: Fira Gran Via（スペイン,バルセロナ)
  • Year and Date: 2014-08-31 – 2014-09-02
• [Presentation] Narrowing of retinal arterioles might reflect smoking sensitivity, a risk of chronic obstructive pulmonary disease. (2014)
  • Author(s): Hirayama A, Kawasaki R, Shibata Y, Konta T, Narimatsu H, Kayama T, Yamashita H, Kubota I,
  • Organizer: The Association for Research in Vision and Ophthalmology 2014 Annual Meeting
  • Place of Presentation: オレンジカントリーコンベンションセンター（アメリカ合衆国オーランド）
  • Year and Date: 2014-05-04 – 2014-05-08