Mst1 promotes progression of dilated cardiomyopathy by modulating immune system
| Project/Area Number |
26461126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MAEJIMA YASUHIRO 東京医科歯科大学, 医学部附属病院, 講師 (40401393)
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| Co-Investigator(Kenkyū-buntansha) |
磯部 光章 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80176263)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI JUNICHI 東京大学, 医学系研究科, 特任准教授 (90313858)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 制御性T細胞 / 自己免疫性心筋炎 / リン酸化 / 心筋炎 / 拡張型心筋症 / キナーゼ |
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| Outline of Final Research Achievements |
We have previously shown that Mst1 phosphorylates FoxO1, a forehead transcription factor, thereby modulating cell survival of cardiomyocytes through induction of nuclear translocation of FoxO1. In this study, based on this finding, we explored that the role of Mst1 on Foxp3, another forehead transcription factor which regulates the function of regulatory T cell (Treg), and found that Mst1 modulates the progression of post-myocarditis dilated cardiomyopathy through phosphorylating Foxp3 through modulating Treg-mediated immune system.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Agains Energy Stress.2015
Author(s)
Y. Ikeda, A. Shitakabe, Y. Maejeima, P. Zhai, S. Sciarretta, J. Toli, M. Nomura, K.Mihara, K. Egashira, M. Ohnishi, M. Abdellatif and J. Sadoshima
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Journal Title
Circulation Research
Volume: 116
Issue: 2
Pages: 264-278
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] mTORC2 regulates cardiac response to stress by inhibiting MST1.2015
Author(s)
Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe M, Frati G, Li H, Sadoshima J.
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Journal Title
Cell Rep
Volume: 11
Issue: 1
Pages: 125-136
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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