Functional analysis of stretch activated channel and oneset mechanisms of cardiomyopathy
| Project/Area Number |
26461139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Iwata Yuko 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (80171908)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心筋症 / 筋ジストロフィー / 癌悪液質 / 筋変性 / 細胞内Ca異常 / 筋委縮 / 心不全 / カルシウム透過チャネル |
|---|
| Outline of Final Research Achievements |
It was revealed that abnormal Ca2+ increase via stretch activated ion channel (TRPV2) plays an important pathophysiological role in muscular dystrophy or cardiomyopathy. After checking safety and therapeutic potential of TRPV2 inhibition using normal and muscular dystrophic/cardiomyopathic model animals,
it was clealy revealed that TRPV2 inhibition has no toxicity in normal animals and it has good advantage on the muscular dystrophy/cardiomyopathy. On the other hand, muscle damage by cancer cachexia may be induced through TRPV2-independent mechanisms distinct from those in muscular dystrophy or cardiomyopathy.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Lack of TRPV2 impaired thermogenesis in mouse brown adipose tissue.2016
Author(s)
1.Sun, W., Uchida, K., Suzuki, Y., Zhou, Y., Kim, M., Takayama, Y., Takahashi, N., Goto, T., Wakabayashi, S., Kawada, T., Iwata, Y., and Tominaga, M
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Journal Title
EMBO Report
Volume: 17
Issue: 3
Pages: 383-399
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Osmosensation in TRPV2 dominant negative expressing skeletal muscle fibres.2015
Author(s)
Zanou N, Mondin L, Fuster C, Seghers F, Dufour I, de Clippele M, Schakman O, Tajeddine N, Iwata Y, Wakabayashi S, Voets T, Allard B, Gailly P
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Journal Title
JOURNAL OF PHYSIOLOGY
Volume: 593
Pages: 3849-3863
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 新しい心筋症治療薬の開発2015
Author(s)
岩田裕子
Organizer
第2回筋ジストロフィー医療研究会(特別企画)
Place of Presentation
大阪大学中之島センター
Year and Date
2015-10-24
Related Report
Invited
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[Presentation] Absence of TRPV2 impaired BAT thermogenesis in mice2015
Author(s)
Sun W, Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, Tominaga M
Organizer
5th International Ion Channel Conference
Place of Presentation
中国
Year and Date
2015-06-26
Related Report
Int'l Joint Research
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