Elucidation of mechanism of atherosclerosis focusing on arteries, microvessels in perivascular tissues and vasa vasorum in adventitia
| Project/Area Number |
26461141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Tanaka Kimie 東京大学, 保健・健康推進本部, 助教 (30508065)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 動脈硬化 / 血管外膜 / 血管外膜微小血管 / 血管周囲脂肪組織 / 動脈硬化モデルマウス |
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| Outline of Final Research Achievements |
In adventitial area of advanced atherosclerotic lesion, vasa vasorum expands and penetrates into atherosclerotic plaque from the adventitial side, plays as a conduit which supplies lipid and inflammatory cells into the plaque. Adjacent to arteries, there are perivascular adipose tissues, which have plentiful capillary networks. Perivascular adipose tissue is considered to secrete adipocytokines, that control vascular lesion formation. However, the relation between arteries, adventitial vasa vasorum and capillaries in perivascular adipose tissue remains to be elucidated. In this study, the structural and functional relation between arteries, adventitial vasa vasorum and perivascular tissues were evaluated, using spontaneous and mechanically induced vascular lesions in mouse models of atherosclerosis.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice.2017
Author(s)
Hotimah Masdan Salim, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro, Masataka Sata.
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Journal Title
Vascular Pharmacology
Volume: 印刷中
Pages: 19-25
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation2016
Author(s)
Takashima A, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Nishimoto S, Yagi S, Yamada H, Soeki T, Wakatsuki T, Taketani Y, Shimabukuro M, Sata M
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Journal Title
Atherosclerosis
Volume: 254
Pages: 142-150
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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