| Project/Area Number |
26461164
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
千葉 弘文 札幌医科大学, 医学部, 准教授 (40347175)
大塚 満雄 札幌医科大学, 医学部, 講師 (10398323)
黒沼 幸治 札幌医科大学, 医学部, 講師 (40563250)
高橋 素子 札幌医科大学, 医学部, 准教授 (00303941)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA YOSHIHIRO 札幌医科大学, 医学部, 助教 (90643180)
SAITO ATSUSHI 札幌医科大学, 医学部, 助教 (00768939)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 急性肺傷害 / ブレオマイシン / 肺コレクチン / 肺サーファクタントタンパク質A / トル様受容体 / アレルギー性気道炎症 / 肺サーファクタント / 抗炎症 / 抗線維化 / 肺傷害 |
|---|
| Outline of Final Research Achievements |
This study was performed to clarify the importance of pulmonary surfactant protein (SP-A) as an inhibitor of lung injury / fibrosis and allergic airway inflammation and its mechanism, and to show the results that will be a bridge to the therapeutic strategy. In SP-A knockout mice, intrapulmonary inflammation and fibrosis were significantly enhanced under bleomycin stimulation compared with wild type mice. When SP-A was further administered from the respiratory tract, the inflammation was suppressed. Furthermore, in vitro experiments revealed that the inhibitory effect of SP-A against inflammation was based on the inhibition of binding of bleomycin and soluble Toll-like receptor (sTLR2). In addition, the effect of suppressing allergic reaction in respiratory tracts was also confirmed.
|
