Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant protein
| Project/Area Number |
26461164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
千葉 弘文 札幌医科大学, 医学部, 准教授 (40347175)
大塚 満雄 札幌医科大学, 医学部, 講師 (10398323)
黒沼 幸治 札幌医科大学, 医学部, 講師 (40563250)
高橋 素子 札幌医科大学, 医学部, 准教授 (00303941)
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| Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA YOSHIHIRO 札幌医科大学, 医学部, 助教 (90643180)
SAITO ATSUSHI 札幌医科大学, 医学部, 助教 (00768939)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 急性肺傷害 / ブレオマイシン / 肺コレクチン / 肺サーファクタントタンパク質A / トル様受容体 / アレルギー性気道炎症 / 肺サーファクタント / 抗炎症 / 抗線維化 / 肺傷害 |
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| Outline of Final Research Achievements |
This study was performed to clarify the importance of pulmonary surfactant protein (SP-A) as an inhibitor of lung injury / fibrosis and allergic airway inflammation and its mechanism, and to show the results that will be a bridge to the therapeutic strategy. In SP-A knockout mice, intrapulmonary inflammation and fibrosis were significantly enhanced under bleomycin stimulation compared with wild type mice. When SP-A was further administered from the respiratory tract, the inflammation was suppressed. Furthermore, in vitro experiments revealed that the inhibitory effect of SP-A against inflammation was based on the inhibition of binding of bleomycin and soluble Toll-like receptor (sTLR2). In addition, the effect of suppressing allergic reaction in respiratory tracts was also confirmed.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling.2015
Author(s)
Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Yamaguchi Y, Nishitani C, Takamiya R, Saito A, Uehara Y, Hashimoto J, Kurimura Y, Takahashi H, Kuroki Y
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Journal Title
Oncogene
Volume: 34
Pages: 838-845
Related Report
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