Roles of C-type lectins in the development of allergic airway inflammation
Project/Area Number |
26461184
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Chiba University |
Principal Investigator |
Hirose Koichi 千葉大学, 大学院医学研究院, 准教授 (90400887)
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Co-Investigator(Kenkyū-buntansha) |
高取 宏昌 千葉大学, 医学部附属病院, 助教 (30568225)
鈴木 浩太郎 千葉大学, 医学部附属病院, 講師 (90554634)
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Co-Investigator(Renkei-kenkyūsha) |
SUZUKI KOTARO 千葉大学, 医学部附属病院, 講師 (90554634)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | C型レクチン / Dectin-1 / Dectin-2 / アレルギー性気道炎症 / Th2細胞 / Th17細胞 / CD11b陽性樹状細胞 |
Outline of Final Research Achievements |
It is well known that sensitization against fungi is closely associated with severity of asthma, however, the roles of Dectin-1 and Dectin-2, major PRRs for fungi, in HDM-induced allergic airway inflammation remain unclear. In this study, we examined whether Dectin-1 or Dectin-2 is involved in HDM-induced allergic airway inflammation. We found that HDM-induced eosinophil and neutrophil recruitment into the airways was significantly attenuated in Clec7a-/- mice and in Clec4n-/- as compared with that in wild-type (WT) mice. In addition, HDM-induced cytokine production from mediastinum lymph node cells was reduced in HDM-sensitized Clec7a-/- mice and Clec4n-/- mice. Dectin-1 and Dectin-2 were expressed on CD11b+ dendritic cells (DCs), an essential DC subset for the development of allergic inflammation. Taken together, these results suggest that Dectin-1 and Dectin-2expressed on CD11b+ DCs plays a critical role in the induction of HDM-induced allergic airway inflammation.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Helios enhances regulatory T cell function in cooperation with Foxp32015
Author(s)
Takatori H, Kawashima H, Matsuki A, Meguro K, Tanaka S, Iwamoto T, Sanayama Y, Nishikawa N, Tamachi T, Ikeda K, Suto A, Suzuki K, Kagami S, Hirose K, Kubo M, Hori S, Nakajima H
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Journal Title
Arthritis Rheumatol
Volume: 67
Issue: 6
Pages: 1491-502
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Sox5 and c-Maf cooperatively induce Th17 cell differentiation via ROR gamma t induction as downstream targets of Stat32014
Author(s)
Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H
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Journal Title
J Exp Med
Volume: 211
Issue: 9
Pages: 1857-1874
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Dectin-2 promotes house dust mite-induced Th2 and Th17 cell differentiation and allergic airway inflammation in mice.2014
Author(s)
Norimoto, A., Hirose, K., Iwata, A., Tamachi, T., Yokota, M., Takahashi, K., Saijo, S., Iwakura, Y., and Nakajima, H.
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Journal Title
Am. J. Respir. Cell Mol. Biol.
Volume: 印刷中
Issue: 2
Pages: 201-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Prediction of relapse after discontinuation of biologic agents by ultrasonographic assessment in patients with rheumatoid arthritis in clinical remission: high predictive values of total gray-scale and power Doppler scores that represent residual synovial inflammation before discontinuation2014
Author(s)
Iwamoto T, Ikeda K, Hosokawa J, Yamagata M, Tanaka S, Norimoto A, Sanayama Y, Nakagomi D, Takahashi K, Hirose K, Sugiyama T, Sueishi M, Nakajima H
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Journal Title
Arthritis Care Res (Hoboken)
Volume: 66
Pages: 1576-81
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Dectin-1 plays an important role in HDM-induced allergic airway inflammation through the activation of CD11b+ dendritic cells2016
Author(s)
Ito, T., Hirose, K., Norimoto, A., Tamachi, T., Yokota, M., Saku, A., Takatori, H., Saijo, S., Iwakura, Y., Nakajima, H.
Organizer
第16回国際免疫学会
Place of Presentation
Melbourne Convention and Exhibition Centre(Melbourne, Australia)
Year and Date
2016-08-21
Related Report
Int'l Joint Research
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