Elucidation of molecular mechanism of survivin in inflammatory lung disease and development of new gene therapy method
Project/Area Number |
26461203
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Nippon Medical School |
Principal Investigator |
Terasaki Mika 日本医科大学, 医学部, 助教 (50372785)
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Co-Investigator(Kenkyū-buntansha) |
寺崎 泰弘 日本医科大学, 医学部, 准教授 (50332870)
三宅 弘一 日本医科大学, 医学部, 准教授 (90267211)
漆山 博和 日本医科大学, 大学院医学研究科, ポストドクター (20725303)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | サバイビン / 間質性肺炎 / 再生 / 非腫瘍性肺疾患 / 炎症急性期 |
Outline of Final Research Achievements |
Survivin is a protein having two roles of cell proliferation and apoptosis inhibiting function, and focused on the pathology of interstitial pneumonia and analyzed the mechanism of action of this factor. In human and model mice of interstitial pneumonia disease, high expression of survivin was observed mainly in the regenerating alveolar epithelium. Even in cultured cells, similar expression increase was observed by induction of injury, and suppression of survivin remarkably inhibited cell proliferation. Since survivin expression is observed in the regenerating epithelium in various injuries regardless of the cause, it became clear that survivin is indispensable for regeneration upon cell injury.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, with Primary Manifestation as an Upper Eyelid Swelling2016
Author(s)
Kanzaki A, Funasaka Y, Nakamizo M, Shima A, Ryotokuji T, Dan K, Terasaki M, Sugisaki Y, Fukuda Y, Kawana S, Saeki H
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Journal Title
Journal of Nippon Medical School
Volume: 83
Issue: 4
Pages: 177-179
DOI
NAID
ISSN
1345-4676, 1347-3409
Related Report
Peer Reviewed
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[Journal Article] Pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis: a case report and literature review.2016
Author(s)
Kokuho N, Terasaki Y, Urushiyama H, Terasaki M, Kunugi S, Morimoto T, Azuma A, Usuda J, Gemma A, Eishi Y, Shimizu A.
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Journal Title
Hum Pathol.
Volume: 51
Pages: 57-63
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 破骨細胞様巨細胞を伴う子宮平滑筋肉腫の1例2015
Author(s)
寺崎美佳, 寺崎泰弘, 米山剛一, 長濱清隆, 若松恭子, 桑原尚美, 功刀しのぶ, 梶本雄介, 漆山博和, 國保茂暁, 竹下俊行, 清水 章
Organizer
日本病理学会
Place of Presentation
名古屋国際会議場
Year and Date
2015-04-30
Related Report
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[Presentation] 病理診断に苦慮した境界悪性類内膜腫瘍の一例2014
Author(s)
米山 剛一, 飯田 朝子, 川瀬 里衣子, 岩崎 奈央, 加藤 雅彦, 黒瀬 圭輔, 寺崎 美佳, 大橋 隆治, 山本 晃人, 山田 隆, 鴨井 青龍, 土居 大祐, 朝倉 啓文, 竹下 俊行
Organizer
日本婦人科腫瘍学会
Place of Presentation
栃木県総合文化センター
Year and Date
2014-07-17 – 2014-07-19
Related Report
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[Presentation] 偶発的に発見された子宮頸部中腎管腺癌の一例2014
Author(s)
内山 美穂子, 米山 剛一, 加藤 雅彦, 川瀬 里衣子, 黒瀬 圭輔, 寺崎 美佳, 彭 為霞, 石井 英昭, 大橋 隆治, 内藤 善哉, 竹下 俊行
Organizer
関東連合産科婦人科学会
Place of Presentation
東京、日本都市センターホテル
Year and Date
2014-06-21 – 2014-06-22
Related Report
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[Presentation] 卵巣子宮内膜症に合併した境界悪性類内膜腫瘍の1例2014
Author(s)
飯田 朝子, 米山 剛一, 川瀬 里衣子, 岩崎 奈央, 加藤 雅彦, 黒瀬 圭輔, 山本 晃人, 鴨井 青龍, 土居 大祐, 寺崎 美佳, 大橋 隆治, 竹下 俊行
Organizer
関東連合産科婦人科学会
Place of Presentation
東京、日本都市センターホテル
Year and Date
2014-06-21 – 2014-06-22
Related Report
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[Presentation] 子宮頸部乳頭状扁平上皮癌の一例2014
Author(s)
米山 剛一, 川瀬 里衣子, 高屋 茜, 黒瀬 圭輔, 寺崎 美佳
Organizer
日本臨床細胞学会
Place of Presentation
パシフィコ横浜
Year and Date
2014-06-05 – 2014-06-07
Related Report
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[Presentation] Hydrogen-supplemented drinking water protects against naphthalene-gefitinib induced lung injury from inflammation-associated oxidative stress.2014
Author(s)
Y. Terasaki, T. Suzuki1), I. Ohsawa1), H. Urushiyama, M. Terasaki, M. Takahashi, S. Kunugi, A. Ishikawa, N. Kuwahara, N. Kokuho, A. Shimizu
Organizer
ATS (Americam Thoracic Sciety) International Conference
Place of Presentation
San Diego, USA
Year and Date
2014-05-16 – 2014-05-21
Related Report
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[Presentation] 高濃度水素水によるゲフィチニブの急性肺傷害抑制2014
Author(s)
寺崎 泰弘 , 大澤 郁朗, 鈴木 徹也, 渡名喜 梢, 漆山 博和, 寺崎 美佳, 功刀 しのぶ, 福田 悠, 清水 章
Organizer
日本病理学会
Place of Presentation
広島国際会議場
Year and Date
2014-04-24 – 2014-04-26
Related Report
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[Presentation] 子宮ポリープ状異型腺筋腫 (atypical polypoid adenomyoma) および子宮体癌におけるsurvivin 発現検討2014
Author(s)
寺崎美佳, 寺崎泰弘, 若松恭子, 桑原尚美, 高橋美紀子, 永坂真也, 功刀しのぶ, 漆山博和, 野村俊一郎, 益田幸成, 米山剛一, 竹下俊行, 清水 章
Organizer
日本病理学会
Place of Presentation
広島国際会議場
Year and Date
2014-04-24 – 2014-04-26
Related Report
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