The role of CTGF in anti-glomerular basement membrane glomerulonephritis
Project/Area Number |
26461225
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Kyoto University |
Principal Investigator |
YOKOI HIDEKI 京都大学, 医学研究科, 講師 (90378779)
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Co-Investigator(Kenkyū-buntansha) |
笠原 正登 奈良県立医科大学, 医学部, 研究教授 (50393351)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 糸球体腎炎 / 増殖因子 / 腎不全 / タンパク尿 / ノックアウトマウス / 腎臓病 / 炎症 / 細胞外基質 / 腎炎 / 腎臓 / TGF-β |
Outline of Final Research Achievements |
In this study, we induced anti-GBM glomerulonephritis in podocyte-specific CTGF knockout mice.These mice exhibited no improvement of proteinuria, crescentic formation, mesangial expansion and macrophage infiltration. Therefore, we generated mesangial cell-CTGF knockout mice (Mes-CTGF cKO mice) using PDGFR-alpha-Cre mice. Mes-CTGF cKO mice showed reduction of crescentic formation, mesangial expansion, proteinuria, TGF-beta1, alpha-SMA, fibronectin and MCP1 expression. Infiltration of macrophages was also inhibited and the ratio of M1 macrophage/M2 macrophage was significantly reduced.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.2017
Author(s)
Mori KP, Yokoi H, Kasahara M, Imamaki H, Ishii A, Kuwabara T, Koga K, Kato Y, Toda N, Ohno S, Kuwahara K, Endo T, Nakao K, Yanagita M, Mukoyama M, Mori K.
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Journal Title
J Am Soc Nephrol.
Volume: 28
Issue: 1
Pages: 278-289
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Crucial role of mesangial cell-derived connective tissue growth factor in a mouse model of anti-glomerular basement membrane glomerulonephritis.2017
Author(s)
Toda N, Mori K, Kasahara M, Ishii A, Koga K, Ohno S, Mori KP. Kato Y, Osaki K, Kuwabara T, Kojima K, Taura D, Sone M, Matsusaka T, Nakao K, Mukoyama M, Yanagita M, Yokoi H.
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 42114-42114
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition.2017
Author(s)
Kato Y, Mori K, Kasahara M, Osaki K, Ishii A, Mori KP, Toda N, Ohno S, Kuwabara T, Tokudome T, Kishimoto I, Saleem MA, Matsusaka T, Nakao K, Mukoyama M, Yanagita M, Yokoi H
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Journal Title
Scientific Reports
Volume: in press
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.2016
Author(s)
Ohno S, Yokoi H, Mori K, Kasahara M, Kuwahara K, Fujikura J, Naito M, Kuwabara T, Imamaki H, Ishii A, Saleem MA, Numata T, Mori Y, Nakao K, Yanagita M, Mukoyama M
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 27192-27192
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] MicroRNA-26a inhibits TGF-β-induced extracellular matrix expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy.2015
Author(s)
Koga K, Yokoi H, Mori K, Kasahara K, Kuwabara T, Imamaki H, Ishii A, Mori KP, Kato Y, Ohno S, Toda N, Saleem MA, Sugawara A, Nakao K, Yanagita M, Mukoyama M.
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Journal Title
Diabetologia
Volume: 58
Issue: 9
Pages: 2169-80
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients.2015
Author(s)
Imamaki H, Ishii A, Yokoi H, Kasahara M, Kuwabara T, Mori KP, Kato Y, Kuwahara T, Satoh M, Nakatani K, Saito Y, Tomosugi N, Sugawara A, Nakao K, Mukoyama M, Yanagita M, Mori K.
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Journal Title
PLoS One
Volume: 10
Issue: 7
Pages: 99-106
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Predictive significance of kidney myeloid-related protein 8 expression in patients with obesity- or type 2 diabetes-associated kidney diseases2014
Author(s)
Kuwabara T, Mori K, Kasahara M, Yokoi H, Imamaki H, Ishii A, Koga K, Sugawara A, Yasuno S, Ueshima K, Morikawa T, Konishi Y, Imanishi M, Nishiyama A, Nakao K, Mukoyama M
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Journal Title
PloS One
Volume: 9
Issue: 2
Pages: e88942-e88942
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The role of mesangial cell-derived CTGF in anti-glomerular membrane nephritis2014
Author(s)
Toda, Yokoi, Kasahara, Mori, Kuwaara, Imamaki, Sugawara, Matsusaka, Nakao, Yanagita, Mukoyama
Organizer
American Society of Nephrology
Place of Presentation
Philadelphia, USA
Year and Date
2014-11-13 – 2014-11-15
Related Report
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