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The role of CTGF in anti-glomerular basement membrane glomerulonephritis

Research Project

Project/Area Number 26461225
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKyoto University

Principal Investigator

YOKOI HIDEKI  京都大学, 医学研究科, 講師 (90378779)

Co-Investigator(Kenkyū-buntansha) 笠原 正登  奈良県立医科大学, 医学部, 研究教授 (50393351)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords糸球体腎炎 / 増殖因子 / 腎不全 / タンパク尿 / ノックアウトマウス / 腎臓病 / 炎症 / 細胞外基質 / 腎炎 / 腎臓 / TGF-β
Outline of Final Research Achievements

In this study, we induced anti-GBM glomerulonephritis in podocyte-specific CTGF knockout mice.These mice exhibited no improvement of proteinuria, crescentic formation, mesangial expansion and macrophage infiltration.
Therefore, we generated mesangial cell-CTGF knockout mice (Mes-CTGF cKO mice) using PDGFR-alpha-Cre mice. Mes-CTGF cKO mice showed reduction of crescentic formation, mesangial expansion, proteinuria, TGF-beta1, alpha-SMA, fibronectin and MCP1 expression. Infiltration of macrophages was also inhibited and the ratio of M1 macrophage/M2 macrophage was significantly reduced.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 6 results,  Acknowledgement Compliant: 7 results) Presentation (6 results) (of which Int'l Joint Research: 3 results) Remarks (3 results)

  • [Int'l Joint Research] Bristol University(英国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.2017

    • Author(s)
      Mori KP, Yokoi H, Kasahara M, Imamaki H, Ishii A, Kuwabara T, Koga K, Kato Y, Toda N, Ohno S, Kuwahara K, Endo T, Nakao K, Yanagita M, Mukoyama M, Mori K.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 28 Issue: 1 Pages: 278-289

    • DOI

      10.1681/asn.2015101168

    • NAID

      120005820888

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crucial role of mesangial cell-derived connective tissue growth factor in a mouse model of anti-glomerular basement membrane glomerulonephritis.2017

    • Author(s)
      Toda N, Mori K, Kasahara M, Ishii A, Koga K, Ohno S, Mori KP. Kato Y, Osaki K, Kuwabara T, Kojima K, Taura D, Sone M, Matsusaka T, Nakao K, Mukoyama M, Yanagita M, Yokoi H.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 42114-42114

    • DOI

      10.1038/srep42114

    • NAID

      120005997757

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition.2017

    • Author(s)
      Kato Y, Mori K, Kasahara M, Osaki K, Ishii A, Mori KP, Toda N, Ohno S, Kuwabara T, Tokudome T, Kishimoto I, Saleem MA, Matsusaka T, Nakao K, Mukoyama M, Yanagita M, Yokoi H
    • Journal Title

      Scientific Reports

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.2016

    • Author(s)
      Ohno S, Yokoi H, Mori K, Kasahara M, Kuwahara K, Fujikura J, Naito M, Kuwabara T, Imamaki H, Ishii A, Saleem MA, Numata T, Mori Y, Nakao K, Yanagita M, Mukoyama M
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 27192-27192

    • DOI

      10.1038/srep27192

    • NAID

      120007100128

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Targeting the fatty acid transport protein CD36, a class B scavenger receptor, in the treatment of renal disease.2016

    • Author(s)
      Yokoi H, Yanagita M
    • Journal Title

      Kidney International

      Volume: 89 Issue: 4 Pages: 740-742

    • DOI

      10.1016/j.kint.2016.01.009

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MicroRNA-26a inhibits TGF-β-induced extracellular matrix expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy.2015

    • Author(s)
      Koga K, Yokoi H, Mori K, Kasahara K, Kuwabara T, Imamaki H, Ishii A, Mori KP, Kato Y, Ohno S, Toda N, Saleem MA, Sugawara A, Nakao K, Yanagita M, Mukoyama M.
    • Journal Title

      Diabetologia

      Volume: 58 Issue: 9 Pages: 2169-80

    • DOI

      10.1007/s00125-015-3642-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients.2015

    • Author(s)
      Imamaki H, Ishii A, Yokoi H, Kasahara M, Kuwabara T, Mori KP, Kato Y, Kuwahara T, Satoh M, Nakatani K, Saito Y, Tomosugi N, Sugawara A, Nakao K, Mukoyama M, Yanagita M, Mori K.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: 99-106

    • DOI

      10.1371/journal.pone.0132539

    • NAID

      120005678176

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Predictive significance of kidney myeloid-related protein 8 expression in patients with obesity- or type 2 diabetes-associated kidney diseases2014

    • Author(s)
      Kuwabara T, Mori K, Kasahara M, Yokoi H, Imamaki H, Ishii A, Koga K, Sugawara A, Yasuno S, Ueshima K, Morikawa T, Konishi Y, Imanishi M, Nishiyama A, Nakao K, Mukoyama M
    • Journal Title

      PloS One

      Volume: 9 Issue: 2 Pages: e88942-e88942

    • DOI

      10.1371/journal.pone.0088942

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Microalbuminuric stage of diabetic nephropathy is characterized with enhancement of total nephron albumin filtration and reabsorption2016

    • Author(s)
      Keita P. Mori, Hideki Yokoi, Masato Kasahara, Takashige Kuwabara, Hirotaka Imamaki, Akira Ishii, Kazuwa Nakao, Motoko Yanagita, Masashi Mukoyama, Kiyoshi Mori
    • Organizer
      Asian Pacific Congress of Nephrology (APCN)
    • Place of Presentation
      Perth (Australia)
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of CTGF in Peritoneal Fibrosis in Mice2016

    • Author(s)
      Naohiro Toda, Masato Kasahara, Kiyoshi Mori, Akira Ishii, Masashi Mukoyama1, Motoko Yanagita, Hideki Yokoi
    • Organizer
      Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Chicago (USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗糸球体基底膜抗体腎炎におけるCTGFの役割2016

    • Author(s)
      戸田尚宏、横井秀基、笠原正登、森 潔、桒原孝成、石井輝、古賀健一、松阪泰二、中尾一和、柳田素子、向山政志
    • Organizer
      第53回日本臨床分子医学会総会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Role of N-type calcium channel in a mouse model of diabetic nephropathy2015

    • Author(s)
      Ohno, Yokoi, Mori, Kasahara, Kuwabara, Saleem, Nakao, Yanagita, Mukoyama
    • Organizer
      Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] メサンギウム細胞由来CTGFのマクロファージに対する役割2015

    • Author(s)
      戸田尚宏、横井秀基、笠原正登、森 潔、桒原孝成、今牧博貴、石井輝、古賀健一、 菅原照、松阪泰二、中尾一和、柳田素子、向山政志
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-07
    • Related Report
      2015 Research-status Report
  • [Presentation] The role of mesangial cell-derived CTGF in anti-glomerular membrane nephritis2014

    • Author(s)
      Toda, Yokoi, Kasahara, Mori, Kuwaara, Imamaki, Sugawara, Matsusaka, Nakao, Yanagita, Mukoyama
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-13 – 2014-11-15
    • Related Report
      2014 Research-status Report
  • [Remarks] 京都大学大学院医学研究科 腎臓内科学

    • URL

      http://www.kidney.kuhp.kyoto-u.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 京都大学大学院医学研究科腎臓内科学

    • URL

      http://www.kidney.kuhp.kyoto-u.ac.jp/

    • Related Report
      2015 Research-status Report
  • [Remarks] 京都大学大学院医学研究科腎臓内科学

    • URL

      http://www.kidney.kuhp.kyoto-u.ac.jp/research/yokoi.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2022-02-16  

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