| Project/Area Number |
26461269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nagoya University |
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Principal Investigator |
KAWAI Kaori 名古屋大学, 医学系研究科, 研究員 (80398007)
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| Co-Investigator(Kenkyū-buntansha) |
祖父江 元 名古屋大学, 医学系研究科, 特任教授 (20148315)
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| Co-Investigator(Renkei-kenkyūsha) |
KATSUNO Masahisa 名古屋大学, 大学院医学系研究科, 教授 (50402566)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ALS / dynactin-1 / ノックアウトマウス / 神経変性疾患 / 筋萎縮性側索硬化症 / モデルマウス / 脳神経外科 / 孤発性ALS / 脳神経疾患 |
|---|
| Outline of Final Research Achievements |
To elucidate the pathogenesis of sporadic amyotrophic lateral sclerosis (ALS), we generated motor neuron-specific dynactin-1 knockout mice. In this study, we could not identify ubiquitinated protein included in the ubiquitin-positive aggregates in motor neurons of the spinal anterior horn because of less amount of targeted proteins. There was a need to improve the method for recovering ubiquitinated protein. In the dynactin-1 knockout mice, glial activation detected before appearance of neurodegenerative symptoms, such as tremor and reduction in motor function.
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