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Role of angiotensin for the disturbed microcirculation in the ischemic brain

Research Project

Project/Area Number 26461278
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionSaitama Medical University

Principal Investigator

Hayashi Takeshi  埼玉医科大学, 医学部, 教授 (40314679)

Co-Investigator(Kenkyū-buntansha) 丸山 元  埼玉医科大学, 医学部, 助教 (00646680)
福岡 卓也  埼玉医科大学, 医学部, 講師 (50646221)
栗田 浩樹  埼玉医科大学, 医学部, 教授 (70262003)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords脳虚血 / 微小循環障害 / 再灌流 / アンギオテンシン
Outline of Final Research Achievements

Deranged microcirculation is one of the reasons of unsatisfactory results of thrombolytic therapy for ischemic stroke. We investigated role of angiotensin for the microcirculation disturbance in the ischemic brain.
With use of type 1 angiotensin II receptor (AT1) knock-out and wld-type mice, we observed adhesion and rolling of leukocytes and platelets on the microvessel wall in the brain after transient ischemia. Fewer numbers of cells showed adhesion and rolling in the AT1 knock-out mice. Then we used type 2 angiotensin II receptor (AT2) knock-out and wld-type mice, and observed in a same manner. Contrarilly, AT2 knock-out mice showed more adhesion and rolling of leukocytes and platelets in the brain microvessels after transient ischemia.
Blocking AT1 and stimulation of AT2 are associated with better prognosis in human stroke. Our results indicate that improved microcirculation could underlie this brain-protective effect.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Platelet-endothelial cell interaction in brain microvessels of angiotensin II type-2 receptor knockout mice following transient bilateral common carotid artery occlusion.2015

    • Author(s)
      Fukuoka T, Hayashi T, Hirayama M, Maruyama H, Mogi M, Horiuchi M, Takao M, Tanahashi N.
    • Journal Title

      J Thromb Thrombolysis

      Volume: 40 Issue: 4 Pages: 401-405

    • DOI

      10.1007/s11239-015-1254-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] アンギオテンシンII type 1レセプター欠損マウスにおける脳虚血再灌流後の脳軟膜血管での血小板動態の検討2014

    • Author(s)
      福岡卓也、林 健、平山真紀子、丸山元、棚橋紀夫
    • Organizer
      第26回日本脳循環代謝学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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