The new therapy for cerebral infarction by modulating Keap1/Neaf2 system
Project/Area Number |
26461279
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Osaka City University (2015-2016) Keio University (2014) |
Principal Investigator |
Abe Takato 大阪市立大学, 大学院医学研究科, 准教授 (30365233)
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Co-Investigator(Kenkyū-buntansha) |
畝川 美悠紀 慶應義塾大学, 医学部(信濃町), 特任講師 (10548481)
高橋 慎一 慶應義塾大学, 医学部(信濃町), 准教授 (20236285)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | DMF / dimethylfumarate / cerebral ischemia / Nrf2 / 脳虚血 / dimethyl fumarate |
Outline of Final Research Achievements |
To investigate the effects of Keap1/Nrf2 system on cerebral ischemia, we tested whether dimethyl fumarate (DMF) and D-serine affect the stroke volume in mice middle cerebral artery occlusion model. DMF reduced stroke volume when it's administrated twice/day from 10 min after reperfusion. In serine racemase (SRR) null mice, in which the content of D-serine is markedly reduced, the stroke volume was significantly smaller than wild type mice.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Cellular origin and regulation of D- and L-serine in vitro and in vivo models of cerebral ischemia.2014
Author(s)
Abe T, Suzuki M, Sasabe J, Takahashi S, Unekawa M, Mashima K, Iizumi T, Hamase K, Konno R, Aiso S, Suzuki N.
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Journal Title
J Cereb Blood Flow Metab
Volume: 34(12)
Issue: 12
Pages: 1928-1935
DOI
Related Report
Peer Reviewed / Open Access
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