2016 Fiscal Year Final Research Report
The new therapy for cerebral infarction by modulating Keap1/Neaf2 system
Project/Area Number |
26461279
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Osaka City University (2015-2016) Keio University (2014) |
Principal Investigator |
Abe Takato 大阪市立大学, 大学院医学研究科, 准教授 (30365233)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | DMF |
Outline of Final Research Achievements |
To investigate the effects of Keap1/Nrf2 system on cerebral ischemia, we tested whether dimethyl fumarate (DMF) and D-serine affect the stroke volume in mice middle cerebral artery occlusion model. DMF reduced stroke volume when it's administrated twice/day from 10 min after reperfusion. In serine racemase (SRR) null mice, in which the content of D-serine is markedly reduced, the stroke volume was significantly smaller than wild type mice.
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Free Research Field |
神経内科
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