Zinc effect for iron efflux from the neuronal cells
Project/Area Number |
26461291
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
河野 智 浜松医科大学, 医学部附属病院, 講師 (40397386)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 鉄 / 亜鉛 / フェロポルチン / セルロプラスミン / トランスフェリン / 亜鉛トランスポーター / マンガン / 鉄酸化作用 / 酸化ストレス / 無セルロプラスミン血症 / 神経変性 / ヘプシジン / ヘファエスチン / アストロサイト |
Outline of Final Research Achievements |
Zinc can play an important role in the stability of ferroportin and ferrous iron binding to transferrin. We found that zinc transporter ZnT10 is localized to the plasma membrane and functional in Mn metabolism by effluxing cytosolic Mn. Because zinc has antioxidant activity, treatment with zinc may be useful in patients with neurodegeneration with brain iron accumulation to diminish iron accumulation in the brain.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Direct comparison of manganese detoxification/efflux proteins and molecular characterization of ZnT10 protein as a manganese transporter.2016
Author(s)
Nishito Y, Tsuji N, Fujishiro H, Takeda TA, Yamazaki T, Teranishi F, Okazaki F, Matsunaga A, Tuschl K, Rao R, Kono S, Miyajima H, Narita H, Himeno S, Kambe T.
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Journal Title
J Biol Chem
Volume: 291
Pages: 14773-14787
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Copper accumulates in hemosiderins in livers of patients with iron overload syndromes.2015
Author(s)
Ono Y, Ishigami M, Hayashi K, Wakusawa S, Hayashi H, Kumagai K, Morotomi N, Yamashita T, Kawanaka M, Watanabe M, Ozawa H, Tai M, Miyajima H, Yoshioka K, Hirooka Y, Goto H.
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Journal Title
J Clin Transl Hepatol
Volume: 3
Pages: 85-92
Related Report
Peer Reviewed
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