Immunoblobulin therapy targeting the main immunogenic region of acetylcholine receptor: Animal experiment
Project/Area Number |
26461302
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Nagasaki Institute of Applied Science |
Principal Investigator |
MOTOMURA MASAKATSU 長崎総合科学大学, 工学(系)研究科(研究院), 教授 (70244093)
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Co-Investigator(Kenkyū-buntansha) |
白石 裕一 長崎大学, 病院(医学系), 講師 (40423644)
中田 るか 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (70549394)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 重症筋無力症 / アセチルコリン受容体(AChR)抗体 / 主要免疫原性領域(MIR) / 免疫グロブリン療法 / アセチルコリン受容体抗体 / 主要免疫原性領域 / 保護抗体 |
Outline of Final Research Achievements |
The goal of this study is to develop an immunoglobulin therapy targeting the major immunogenic region (MIR) in the treatment of patients with Acetylcholine Receptor (AChR) antibody positive myasthenia gravis (MG). In this study, we examined its practicality in animal experiments. A protective antibody was prepared by removing the complement binding site of the mAb35 monoclonal antibody, against the common AChR-MIR of humans and rats, and whether or not disease transfer by the antibody can be prevented was examined in an animal experiment in vivo. Unfortunately, in this study, it was not possible to prepare mAb35 mutant antibody which does not cause destruction by complement. We will continue to study MIR antibodies that will not cause complement activation.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Anti-MuSK Antibody-positive Myasthenia Gravis Mimicking Amyotrophic Lateral Sclerosis2015
Author(s)
Furuta N, Ishizawa K, Shibata M, Tsukagoshi S, Nagamine S, Makioka K, Fujita Y, Ikeda M, Yoshimura S, Motomura M, Okamoto K, Ikeda Y.
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Journal Title
Internal Medicine
Volume: 54
Issue: 19
Pages: 2497-2501
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Antibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis2015
Author(s)
Nakajima H, Motomura M, Tanaka K, Fujikawa A, Nakata R, Maeda Y, Shima T, Mukaino A, Yoshimura S, Miyazaki T, Shiraishi H, Kawakami A, Tsujino A
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Journal Title
BMJ Open
Volume: 5
Issue: 4
Pages: e007766-e007766
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases.2014
Author(s)
chinose K, Arima K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Nakajima H, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Origuchi T, Motomura M, Kawakami A.
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Journal Title
Clin Immunol.
Volume: 157
Issue: 2
Pages: 114-120
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction2014
Author(s)
Sumimasa Arimura, Takashi Okada, Tohru Tezuka, Tomoko Chiyo, Yuko Kasahara, Toshiro Yoshimura, Masakatsu Motomura, Nobuaki Yoshida, David Beeson, Shin’ichi Takeda, Yuji Yamanashi
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Journal Title
Science
Volume: 345
Issue: 6203
Pages: 1505-1508
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Insights into the classification of myasthenia gravis2014
Author(s)
Akaishi T, Yamaguchi T, Suzuki Y, Nagane Y, Suzuki S, Murai H, Imai T,Motomura M, Fujihara K, Aoki M, Utsugisawa K
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Journal Title
PLoS One
Volume: 9
Issue: 9
Pages: e106757-e106757
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Quality of life in purely ocular myasthenia in Japan2014
Author(s)
Suzuki S, Murai H, Imai T, Nagane Y, Masuda M, Tsuda E, Konno S, Oji S, NakaneS, Motomura M, Suzuki N, Utsugisawa K
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Journal Title
BMC Neurol
Volume: 14
Issue: 1
Pages: 142-142
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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