| Project/Area Number |
26461305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
三澤 園子 千葉大学, 医学部附属病院, 講師 (30375753)
平野 成樹 千葉大学, 医学部附属病院, 講師 (60375756)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 神経障害性疼痛 / 軸索興奮性測定 / 脳機能画像 / 軸索興奮性 / 無髄線維 / 機能的MRI / 慢性疼痛 / 痛覚刺激脳誘発電位 |
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| Outline of Final Research Achievements |
We aimed to develop methods to evaluate changes in the peripheral and central nervous systems by using axonal excitability testing, pain-related brrain potentials, and functional brain imagings. Compared with normal controls, patients with neuropathic pain showed significantly increased sodium currents in the peripheral sensory axons, exaggerated pain-related brain potentials, and increased cerebral blood flow in the anterior cingulate gyrus. These findings suggest that peripheral generation of extopic impulses could lead to central sensitization, particularly in the limbic system, and thereby chronic persistent pain.
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