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Crosstalk between erythropoiesis and iron homeostasis

Research Project

Project/Area Number 26461400
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionKanazawa Medical University (2016-2017)
Kyoto University (2014-2015)

Principal Investigator

KAWABATA Hiroshi  金沢医科大学, 医学部, 教授 (10329401)

Co-Investigator(Renkei-kenkyūsha) TOMOSUGU Naohisa  金沢医科大学, 総合医学研究所, 教授 (80155580)
Research Collaborator MASUDA Taro  
OISHI Shinya  
SAKAMATO Soichoro  
UCHIYAMA Tatsuki  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords血液内科 / 鉄代謝 / ヘプシジン / フェリチン / 赤血球造血 / 血液内科学 / 無効造血 / エリスロフェロン / GDF15 / ヘモクロマトーシス / 鉄芽球性貧血
Outline of Final Research Achievements

The erythropoietic system consumes a large amount of iron, and hepcidin regulates systemic iron homeostasis. We developed a hepcidin-promoter bioassay system and identified several compounds that inhibit hepcidin expression. Iron is mainly carried by transferrin in the circulation and taken up by cells through transferrin receptor 1. We found that H-ferritin, an iron storage protein, can be also taken up by the cells through the same receptor with different manners. H-ferritin suppressed BFU-erythroid colony formation in vitro. We also found that elevated pre-transplant serum hepcidin or ferritin levels are associated with poorer prognosis and delayed platelet engraftment in patients with hematologic malignancies.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015 2014 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Invited: 2 results) Remarks (3 results)

  • [Journal Article] High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation.2017

    • Author(s)
      Sakamoto S, Kawabata H, Kanda J, Uchiyama T, Mizumoto C, Kitano T, Kondo T, Hishizawa M, Tomosugi N, Takaori-Kondo A
    • Journal Title

      Cancer Med

      Volume: 6 Issue: 1 Pages: 120-128

    • DOI

      10.1002/cam4.974

    • NAID

      120005997797

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis2017

    • Author(s)
      Kawabata Hiroshi
    • Journal Title

      International Journal of Hematology

      Volume: 107 Issue: 1 Pages: 31-43

    • DOI

      10.1007/s12185-017-2365-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overview2017

    • Author(s)
      川端 浩
    • Journal Title

      Rinsho Ketsueki

      Volume: 58 Issue: 4 Pages: 327-328

    • DOI

      10.11406/rinketsu.58.327

    • NAID

      130006882214

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Progress in iron metabolism research2017

    • Author(s)
      川端 浩
    • Journal Title

      Rinsho Ketsueki

      Volume: 58 Issue: 10 Pages: 1864-1871

    • DOI

      10.11406/rinketsu.58.1864

    • NAID

      130006132656

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iron-refractory iron deficiency anemia2016

    • Author(s)
      川端浩
    • Journal Title

      Rinsho Ketsueki

      Volume: 57 Issue: 2 Pages: 104-109

    • DOI

      10.11406/rinketsu.57.104

    • NAID

      130005132711

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of growth differentiation factor 15 in the pathogenesis of primary myelofibrosis.2015

    • Author(s)
      Uchiyama T, Kawabata H, Miura Y, Yoshioka S, Iwasa M, Yao H, Sakamoto S, Fujimoto M, Haga H, Kadowaki N, Maekawa T, Takaori-Kondo A.
    • Journal Title

      Cancer Medicine

      Volume: 4 Issue: 10 Pages: 1558-1572

    • DOI

      10.1002/cam4.502

    • NAID

      120005844250

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] H-ferritin is preferentially incorporated by human erythroid cells through transferrin receptor 1 in a threshold-dependent manner.2015

    • Author(s)
      Sakamoto S, Kawabata H, Masuda T, Uchiyama T, Mizumoto C, Ohmori K, Koeffler HP, Kadowaki N, Takaori-Kondo A
    • Journal Title

      PloS one

      Volume: 10 Issue: 10 Pages: e0139915-e0139915

    • DOI

      10.1371/journal.pone.0139915

    • NAID

      120005712943

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression2015

    • Author(s)
      Kawabata H, Uchiyama T, Sakamoto S, Kanda J, Oishi S, Fujii N, Tomosugi N, Kadowaki N, Takaori-Kondo A
    • Journal Title

      Experimental Hematology

      Volume: in press Issue: 5 Pages: 404-413.e5

    • DOI

      10.1016/j.exphem.2015.01.005

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 赤血球の生理機能と産生調節2015

    • Author(s)
      川端浩 高折晃史
    • Journal Title

      日本内科学会雑誌

      Volume: 104 Pages: 1367-1374

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 造血器腫瘍における鉄代謝異常症2017

    • Author(s)
      川端浩
    • Organizer
      第41回日本鉄バイオサイエンス学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 鉄代謝研究の進歩2017

    • Author(s)
      川端浩
    • Organizer
      第79回日本血液学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] (シンポジウム)Roles of transferrin receptors in erythropoiesis2015

    • Author(s)
      川端浩, 坂本宗一郎, 増田太郎, 内山達樹, 大森勝之, Koeffler HP, 高折晃史
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム(金沢市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] (シンポジウム)多中心性キャッスルマン病にみられる高ヘプシジン血症と炎症性貧血2015

    • Author(s)
      川端浩
    • Organizer
      第39回日本鉄バイオサイエンス学会学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Year and Date
      2015-08-30
    • Related Report
      2015 Research-status Report
  • [Presentation] (シンポジウム)日本人にみられる遺伝性の鉄過剰症─臨床像、診断プロセス、および病態に関する考察─2015

    • Author(s)
      川端浩
    • Organizer
      第39回日本鉄バイオサイエンス学会学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
  • [Presentation] Hフェリチンは赤芽球系細胞に特異的に取り込まれて赤血球造血を抑制する2014

    • Author(s)
      坂本 宗一郎、川端 浩、内山 達樹、門脇 則光、高折 晃史
    • Organizer
      第38回日本鉄バイオサイエンス学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-07
    • Related Report
      2014 Research-status Report
  • [Remarks] 造血制御研究

    • URL

      https://www.kuhp.kyoto-u.ac.jp/~hemonc/research/regulation.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 造血制御研究

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~hemonc/research/regulation.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 京都大学大学院医学研究科 血液・腫瘍内科学 造血制御研究

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~hemonc/research/regulation.html

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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