| Project/Area Number |
26461428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kumamoto University |
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Principal Investigator |
SATOU YORIFUMI 熊本大学, 大学院先導機構, 准教授 (70402807)
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| Research Collaborator |
MIYAZATO Paola 熊本大学, 大学院先導機構, 博士研究員
UTSUNOMIYA Atae 今村病院分院, 血液内科, 医師
KATSUYA Hiroo 熊本大学, エイズ学研究センター, 博士研究員
MATSUO Misaki 熊本大学, 医学生命科学研究科, 大学院生
TOKUNAGA Michiyo 熊本大学, エイズ学研究センター, 技術補佐員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ウイルス / 白血病 / HTLV-1 / エピジェネディスクス / ATL / 成人T細胞白血病 / ヒトT細胞白血病ウイルス / エピジェネティクス / ウイルス感染症 / がん / ゲノム / 微生物 / 癌 |
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| Outline of Final Research Achievements |
I have analyzed epigenetic features of HTLV-1 provirus in ATL cell lines and PBMCs of ATL patients, and then identified a DNA-binding protein CTCF directly binds to HTLV-1 provirus (Satou et al, 2016). CTCF is known as a key molecule for epigenetic regulation of human genome. Our result suggests that CTCF should also play a role in regulation of HTLV-1 proviral transcription. In terms of integration site analysis, we have collected longitudinal clinical samples of ATL patients and HTLV-1 asymptomatic carriers. I am going to continue and extend this research.
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