HTLV-1 proviral research for the control of ATL
| Project/Area Number |
26461428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kumamoto University |
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Principal Investigator |
SATOU YORIFUMI 熊本大学, 大学院先導機構, 准教授 (70402807)
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| Research Collaborator |
MIYAZATO Paola 熊本大学, 大学院先導機構, 博士研究員
UTSUNOMIYA Atae 今村病院分院, 血液内科, 医師
KATSUYA Hiroo 熊本大学, エイズ学研究センター, 博士研究員
MATSUO Misaki 熊本大学, 医学生命科学研究科, 大学院生
TOKUNAGA Michiyo 熊本大学, エイズ学研究センター, 技術補佐員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ウイルス / 白血病 / HTLV-1 / エピジェネディスクス / ATL / 成人T細胞白血病 / ヒトT細胞白血病ウイルス / エピジェネティクス / ウイルス感染症 / がん / ゲノム / 微生物 / 癌 |
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| Outline of Final Research Achievements |
I have analyzed epigenetic features of HTLV-1 provirus in ATL cell lines and PBMCs of ATL patients, and then identified a DNA-binding protein CTCF directly binds to HTLV-1 provirus (Satou et al, 2016). CTCF is known as a key molecule for epigenetic regulation of human genome. Our result suggests that CTCF should also play a role in regulation of HTLV-1 proviral transcription. In terms of integration site analysis, we have collected longitudinal clinical samples of ATL patients and HTLV-1 asymptomatic carriers. I am going to continue and extend this research.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome2016
Author(s)
Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan A, Nakao M, and Bangham CRM.
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Journal Title
PNAS
Volume: in press
Issue: 11
Pages: 3054-3059
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Fibrocytes differ from macrophages but can be infected with HIV-1.2015
Author(s)
M. Hashimoto, H. Nasser, F. Bhuyan, N. Kuse, Y. Satou, S. Harada, K. Yoshimura, J. Sakuragi, K. Monde, Y. Maeda, S. Welbourn, K. Strebel, E.W.A. El-Wahab, M. Miyazaki , S. Hattori, N. Chutiwitoonchai, M. Hiyoshi, S. Oka, M. Takiguchi, S. Suzu.
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Journal Title
The Journal of Immunology
Volume: 195
Issue: 9
Pages: 4341-4350
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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