| Project/Area Number |
26461441
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Mie University |
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Principal Investigator |
Tawara Isao 三重大学, 医学系研究科, 助教 (80378380)
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| Co-Investigator(Kenkyū-buntansha) |
吉田 恭子 (今中恭子 / 吉田 恭子(今中恭子)) 三重大学, 医学系研究科, 准教授 (00242967)
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| Research Collaborator |
Kitano Shigehisa 国立がん研究センター, 中央病院, 医員 (60402682)
Ito Ayumu 国立がん研究センター, 中央病院, 医員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | GVHD / テネイシン-C / テネイシン-Ｃ / 慢性GVHD |
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| Outline of Final Research Achievements |
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for refractory hematological malignancies. Complication occured after allo-HSCT such as graft-vs-host disease (GVHD) is an obstacle for successful allo-HSCT. Pathophysioligy of chronic GVHD (cGVHD) that features tissue fibrosis is still unclear and standard therpy for cGVHD has not been established yet.
Tenascin-C (TN-C)is involved in tissue fibrosis and its role in cGVHD pathophysiolgy is unknown. In this study, we investigated the role of TN-C in cGVHD using mouse model and clinical samples. Mouse models demonstrated that TN-C was produced by recipient-origin cells and there was a tendency that GVHD was exacerbated in TN-C-deficient mice. Analysis of relation between TN-C level in patient's plasma and cGVHD onset is underway.
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