Impaired M2 macrophage function in Behcet's disease as a therapeutic target
| Project/Area Number |
26461469
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Nippon Medical School (2015-2016)
Yokohama City University (2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
桐野 洋平 横浜市立大学, 医学部, 講師 (50468154)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ベーチェット病 / M1マクロファージ / M2マクロファージ / IL-10 / CCR2 / CCR1 / HO-1 / CD163 |
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| Outline of Final Research Achievements |
This study aimed to show a critical role of defective anti-inflammatory M2 macrophage function in Behcet’s disease (BD), because previous studies have shown that defective heme oxygenase-1 (HO-1) expression and IL-10 production are involved in BD. We established in vitro M1 and M2 differentiation systems using GM-CSF and M-CSF, respectively. M2 cells preferentially expressed CCR1, which is also functionally impaired in BD, in addition to HO-1 and IL-10, and migrated more sensitively to MIP-1a than M1 cells. These data suggest that M2 macrophage dysfunction is implicated in development of BD inflammation. Furthermore, in vitro induced M1 cells acquired capacity of IL-10 production in presence of M-CSF, indicating the functional plasicity of macrophages. This findings suggested that phenotypic conversion of macrophages is a promising therapeutic strategy for BD.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Continuous evolution of clinical phenotype in 578 Japanese patients with Behcet's disease: a retrospective observational study.2016
Author(s)
Kirino Y, Ideguchi H, Takeno M, Suda A, Higashitani K, Kunishita Y, Takase-Minegishi K, Tamura M, Watanabe T, Asami Y, Uehara T, Yoshimi R, Yamazaki T, Sekiguchi A, Ihata A, Ohno S, Ueda A, Igarashi T, Nagaoka S, Ishigatsubo Y, Nakajima H.
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Journal Title
Arthritis Res Ther.
Volume: 18
Pages: 217-217
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clinical value of capsule endoscopy for detecting small bowel lesions in patients with intestinal Behçet's disease.2016
Author(s)
Arimoto J, Endo H, Kato T, Umezawa S, Fuyuki A, Uchiyama S, Higurashi T,Ohkubo H, Nonaka T, Takeno M, Ishigatsubo Y, Sakai E, Matsuhashi N, Nakajima A
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Journal Title
Dig Endosc.
Volume: 28
Issue: 2
Pages: 179-85
DOI
Related Report
Peer Reviewed
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[Journal Article] Single center study on ethnic and clinical features of Behcet's disease in Moscow, Russia.2015
Author(s)
Lennikov A, Alekberova Z, Goloeva R, Kitaichi N, Denisov L, Namba K, Takeno M, Ishigatsubo Y, Mizuki N, Nasonov E, Ishida S, Ohno S.
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Journal Title
Clin Rheumatol
Volume: 34
Issue: 2
Pages: 321-327
DOI
Related Report
Peer Reviewed
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[Journal Article] The 2nd edition of consensus statements for the diagnosis and management of intestinal Behcet's disease: indication of anti-TNFα monoclonal antibodies.2014
Author(s)
Hisamatsu T, Ueno F, Matsumoto T, Kobayashi K, Koganei K, Kunisaki R, Hirai F,Nagahori M, Matsushita M, Kobayashi K, Kishimoto M, Takeno M, Tanaka M, Inoue N, Hibi T.
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Journal Title
J Gastroenterol
Volume: 49(1)
Issue: 1
Pages: 156-62
DOI
Related Report
Peer Reviewed
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[Presentation] ベーチェット病の病態2016
Author(s)
岳野光洋
Organizer
第119回日本小児科学会学術集会
Place of Presentation
ロイトン札幌（北海道札幌市）
Year and Date
2016-05-13
Related Report
Invited
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