| Project/Area Number |
26461501
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
Kimura Kouji 名古屋大学, 医学系研究科, 准教授 (50425675)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAKWA Yoshichika 名古屋大学, 大学院医学系研究科, 教授 (10212622)
WACHINO Jun-ichi 名古屋大学, 大学院医学系研究科, 講師 (00535651)
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| Research Collaborator |
KITAOKA Kazuki 名古屋大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 薬剤耐性 / インフルエンザ菌 / ペニシリン結合タンパク / Haemophilus influenzae / PBP / インフルエンザ桿菌 / ベータラクタム系薬 / カルバペネム系薬 / 耐性 / 低感受性 |
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| Outline of Final Research Achievements |
Because we obtained a clinical isolate of Haemophilus influenza with reduced carbapenem susceptibility, we analyzed the mechanisms of the reduced carbapenem susceptibility.By the sequencing analysis, we revealed that this clinical isolate harbored insertion in the penicillin-binding protein. We revealed that this insertion was responsible for reduced carbapenem susceptibility by the analysis of natural competent cell and the penicillin-binding protein competitive assay et al..
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