| Project/Area Number |
26461517
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
Ohshima Nobuko 藤田保健衛生大学, 産学連携推進センター, 講師 (60387694)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRANO Daisuke 藤田保健衛生大学, 医学部, 助教 (70767110)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 交差反応性 / ファージ抗体ライブラリー / インフルエンザ / 交叉反応性抗体 / 交叉反応性 / 中和抗体 / インフルエンザウイルス / 交叉反応性中和抗体 |
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| Outline of Final Research Achievements |
In this study, monoclonal antibodies that cross-react with antigenic variants of type A H3N2 influenza virus were isolated from a human phage antibody library and analyzed. The antibodies that bind to both type A and B influenza vaccines are included in these isolated antibodies, but there was no confirmation that the antibodies recognize hemagglutinin which is a target of virus neutralizing antibody. We also succeeded in isolating another antibodies cross-reactive with all antigenic variants of type A H3N2 influenza virus used in this study. If the epitope conserved in type A H3N2 virus strains is determined through the analysis of these antibodies, we believe that in the future it will lead to the development of a vaccine capable of inducing antibodies recognizing the epitope.
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