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Experimental analysis for understanding pathophysiology of rickettsial infection

Research Project

Project/Area Number 26461519
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

ANDO Shuji  国立感染症研究所, ウイルス第一部, 室長 (30360803)

Co-Investigator(Kenkyū-buntansha) 阿戸 学  国立感染症研究所, 免疫部, 部長 (20392318)
Research Collaborator MATSUMURA Takayuki  国立感染症研究所, 免疫部, 主任研究官
ANDOH Masako  鹿児島大学, 農水産獣医学領域獣医学系, 准教授
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsつつが虫病 / 動物モデル / 免疫応答 / 病態発現 / リケッチア / 遺伝子改変マウス / IFNγ / 一酸化窒素
Outline of Final Research Achievements

Scrub typhus caused by Orientia tsutsugamushi (Ot) ranges from lethality to non-lethality depending on Ot serotype, but relationship between pathology and serotype has been unexplained. To clarify serotype-specific pathophysiology, we infected Ot to mice. The main target cells are macrophage and vascular endothelial cells. Therefore we investigated the influence of IFNγ or nitric oxide (NO). By the serotype, increase and decrease in weight was showed as clinical symptom which was the index of infectivity in mice. The sensitivity of IFNγ or NO-knockout mice was high, especially in the IFNγ-knockout mice, weight loss was significant. In the weight loss group, a larger amount of rickettsia in spleen was detected with splenomegaly. A pathogenic difference was observed due to Ot serotype. In particular, the strain-difference was remarkable among the immunodeficient mouse, suggesting that these immune factors are important for infection control, and the mechanism is different.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] 神戸市内で発生し呼吸不全を伴った重症日本紅斑熱の一例2016

    • Author(s)
      瀧口純司、置村健二郎、石井真梨子、岡村佳代子、坂本浩一、稲本真也、安藤秀二
    • Journal Title

      日本感染症学会誌

      Volume: 90 Pages: 120-124

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] リケッチア研究会情報update~リケッチア症の発生状況とトピックスのレビュー2016

    • Author(s)
      安藤秀二、成田雅
    • Organizer
      第23回リケッチア研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] リケッチア・クラミジアの基礎研究の話題2014

    • Author(s)
      安藤秀二
    • Organizer
      日本感染症学会西日本支部会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-10-23 – 2014-10-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 人獣共通感染症2016

    • Author(s)
      安藤秀二
    • Total Pages
      550
    • Publisher
      医薬ジャーナル社
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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