| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Sip1 is the causative gene for Mowat-Wilson syndrome. Sip1 is expressed in the developing neural tube, the neural crest cells, the hippocampus and the cerebral cortex. Sip1 is also expressed in the serotonergic neurons of the raphe nuclei in the brainstem. Serotonergic neurons of the raphe nuclei project throughout the brain widely and secret serotonin. Serotonin acts as key modulator of neural circuits for emotion, mood and physiological response. We generated Sip1-gene conditional knockout mice in the serotonin neurons of the Raphe. We observed abnormal behavior of the Sip1 conditional knockout mice and some abnormal morphology of the serotonergic neurons. The results suggest that Sip1 gene play an important role for serotonergic neuron development and function.
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