Targeting Rab family small G proteins as a novel neuroblastoma therapeutic approach
Project/Area Number |
26461584
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Kobe University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
早川 晶 神戸大学, 医学研究科, 医学研究員 (40379376)
西尾 久英 神戸大学, 医学研究科, 教授 (80189258)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 神経芽腫 / がん幹細胞 / 微小残存病変(MRD) / Rab / 間葉系幹細胞(MSC) / ALDH |
Outline of Final Research Achievements |
More than half of high-risk neuroblastoma patients have experienced tumor relapses and their overall survival rates remain less than 40%. To improve their prognosis, it is necessary to develop a novel therapeutic approach targeting minimal residual disease (MRD) comprised of chemoresistant cancer stem cells (CSCs). In the present study, we have identified a member of Rab family small G proteins (Rabs), which control the development of neuroblastoma CSCs, and its effector protein. We have then characterized their upstream/downstream signaling pathways.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Early detection of tumor relapse/re-growth by consecutive minimal residual disease monitoring in high-risk neuroblastoma patients.2016
Author(s)
Hirase S, Saitoh A, Hartomo TB, Kozaki A, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Yamamoto N, Mori T, Hayakawa A, Iijima K, Nishio H, and Nishimura N.
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Journal Title
Oncol Let
Volume: 12
Issue: 2
Pages: 1119-1123
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma.2015
Author(s)
Hartomo TB, Pham TVH, Yamamoto N, Hirase S, Hasegawa D, Kosaka Y, Matsuo M, Hayakawa A, Takeshima Y, Iijima K, Nishio H, and Nishimura N.
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Journal Title
Int J Oncol
Volume: 46
Issue: 3
Pages: 1089-1098
DOI
Related Report
Peer Reviewed
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[Journal Article] Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients.2015
Author(s)
Yamamoto N, Kozaki A, Hartomo TB, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Hirase S, Mori T, Hayakawa A, Iijima K, Nishio H, and Nishimura N.
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Journal Title
Oncol Let
Volume: 10
Issue: 5
Pages: 3228-3232
DOI
Related Report
Peer Reviewed
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[Presentation] DENN domain protein DENND2A regulates the progression of neuroblastoma.2016
Author(s)
Yamamoto N, Thwin KK, Fujimura J, Nakanishi K, Mori T, Hayakawa A, Nishio H, Matsuo M, Hasegawa D, Kawasaki K, Kosaka Y, Iijima K, and Nishimura N.
Organizer
Advances in Neuroblastoma Research Conference 2016
Place of Presentation
Cairns, Australia
Year and Date
2016-06-19
Related Report
Int'l Joint Research
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[Presentation] Rab6B mediates the progression of neuroblastoma through the interaction with MTMR5.2016
Author(s)
Nishimura N, Pham TVH, Thwin KK, Yamamoto N, Mori T, Hayakawa A, Nishio H, Matsuo M, Hasegawa D, Kawasaki K, Kosaka Y, and Iijima K.
Organizer
Advances in Neuroblastoma Research Conference 2016
Place of Presentation
Cairns, Australia
Year and Date
2016-06-19
Related Report
Int'l Joint Research
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[Presentation] 神経芽腫患者の微小残存病変モニタリング2016
Author(s)
西村範行, Khin Kyaemon Thwin, 山本暢之, 森健, 早川晶, 長谷川大一郎, 川崎圭一郎, 小阪嘉之, 西尾久英, 飯島一誠.
Organizer
第119回日本小児科学会学術集会
Place of Presentation
札幌
Year and Date
2016-05-13
Related Report
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[Presentation] Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients.2015
Author(s)
Uemura S, Yamamoto N, Kozaki A, Nino N, Takafuji S, Yokoi T, Saito A, Ishida T, Hasegawa D, Kawasaki K, Kosaka Y, Mori T, Hayakawa A, Iijima K, Nishio H, and Nishimura N.
Organizer
第57回日本小児血液・がん学会学術集会
Place of Presentation
山梨
Year and Date
2015-11-27
Related Report
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[Presentation] Two high-risk neuroblastoma cases with early detection of tumor relapse/re-growth by consecutive minimal residual disease monitoring.2015
Author(s)
Saito A, Hirase S, Kozaki A, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Hayakawa A, Iijima K, Nishio H, and Nishimura N.
Organizer
11th Asian Society for Pediatric Research
Place of Presentation
大阪
Year and Date
2015-04-15
Related Report
Int'l Joint Research
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[Presentation] Neuroblastoma minimal residual disease markers are differentially expressed in peripheral blood and bone marrow samples.2015
Author(s)
Uemura S, Yamamoto N, Kozaki A, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Hayakawa A, Iijima K, Nishio H, and Nishimura N.
Organizer
11th Asian Society for Pediatric Research
Place of Presentation
大阪
Year and Date
2015-04-15
Related Report
Int'l Joint Research
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[Presentation] 神経芽腫がん幹細胞の発生・分化における細胞内小胞輸送の制御因子Rab6Bの役割.2014
Author(s)
西村範行, Thi Van Huyen Pham, Tri Budi Hartomo, 山本暢之, 平瀬敏志, 早川晶, 矢内友子, 長谷川大一郎, 川崎圭一郎, 小阪嘉之, 松尾雅文, 飯島一誠, 西尾久英.
Organizer
第56回日本小児血液・がん学会学術集会
Place of Presentation
岡山
Year and Date
2014-11-28 – 2014-11-30
Related Report
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[Presentation] Aldehyde dehydrogenase ALDH1A2 regulates cancer stem cell properties in neuroblastoma.2014
Author(s)
Nishimura N, Hartomo TB, Pham TVH, Yamamoto N, Hirase S, Hayakawa A, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Iijima K, Nishio H.
Organizer
第56回日本小児血液・がん学会学術集会
Place of Presentation
岡山
Year and Date
2014-11-28 – 2014-11-30
Related Report
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[Presentation] Aldehyde dehydrogenase 1A2 expression correlates with cancer stem cell properties in neuroblastoma.2014
Author(s)
Nishimura N, Hartomo TB, Pham TVH, Yamamoto N, Hirase S, Hayakawa A, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Takeshima Y, Iijima K, and Nishio H.
Organizer
Advances in Neuroblastoma Research Conference 2014
Place of Presentation
Cologne, Germany
Year and Date
2014-05-13 – 2014-05-16
Related Report
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[Presentation] Induction of ALDH1A2 expression is critical for cancer stem cell properties in neuroblastoma.2014
Author(s)
Nishimura N, Hartomo TB, Pham TVH, Yamamoto N, Hirase S, Hayakawa A, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Takeshima Y, Iijima K, and Nishio H.
Organizer
AACR Annual Meeting 2014
Place of Presentation
San Diego, CA, USA
Year and Date
2014-04-05 – 2014-04-09
Related Report