2016 Fiscal Year Final Research Report
Targeting Rab family small G proteins as a novel neuroblastoma therapeutic approach
| Project/Area Number |
26461584
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
|
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| Research Institution | Kobe University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 神経芽腫 / がん幹細胞 / 微小残存病変(MRD) / Rab |
|---|
| Outline of Final Research Achievements |
More than half of high-risk neuroblastoma patients have experienced tumor relapses and their overall survival rates remain less than 40%. To improve their prognosis, it is necessary to develop a novel therapeutic approach targeting minimal residual disease (MRD) comprised of chemoresistant cancer stem cells (CSCs). In the present study, we have identified a member of Rab family small G proteins (Rabs), which control the development of neuroblastoma CSCs, and its effector protein. We have then characterized their upstream/downstream signaling pathways.
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| Free Research Field |
小児腫瘍学
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