| Project/Area Number |
26461590
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川崎 幸彦 福島県立医科大学, 医学部, 准教授 (00305369)
橋本 浩一 福島県立医科大学, 医学部, 准教授 (50322342)
佐藤 晶論 福島県立医科大学, 医学部, 講師 (60423795)
細矢 光亮 福島県立医科大学, 医学部, 教授 (80192318)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | DAMPs / HMGB1 / 脳炎脳症 / バイオマーカー / HUSマウス / S100A8 / S100A9 / S100A12 / 脳炎 / 脳症 |
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| Outline of Final Research Achievements |
I examined an epidemiological clinical characteristic of Fukushima of the acute encephalitis and encephalopathy and a factor in conjunction with the convalescence to examine a role of DAMPs in the onset, the progress mechanism of the central nerve infectious disease. Disturbance of consciousness and respiratory failure were bad prognosis.
I made some seriously HUS model mouse. Serum HMGB1 level in seriously HUS mouse ware highest at 6hr and decreased 48hr. So participation of DAMPs was suggested for progress mechanism of the HUS. I searched the inflammatory protein using a cerebrospinal fluid specimen at human acute encephalitis and acute encephalopathy onset. Alpha2 macroglobulin in cerebrospinal fluid increased with the acute disseminated encephalomyelitis, and possibility of acute encephalopathy early biomarker was suggested.
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