Analysis of Regenerated Bone Marrow by Adipose-derived stromal cells grown on a hydroxyapatite scaffold
| Project/Area Number |
26461595
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nippon Medical School |
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Principal Investigator |
UEDA TAKAHIRO 日本医科大学, 医学部, 准教授 (20322505)
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| Co-Investigator(Kenkyū-buntansha) |
右田 真 日本医科大学, 医学部, 助教授 (50256963)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 間葉系幹細胞 / 脂肪由来間葉系幹細胞 / 人工骨髄 / 造血幹細胞 / 人口骨髄 / 血管炎 / 幹細胞 / 再生医療 / MSC |
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| Outline of Final Research Achievements |
Regenerated bone marrow created using mouse adipose-derived mesenchymal cells (ADSC) was confirmed to be able to maintain long-term hematopoietic cells subcutaneously in NOD immunodeficient mice and was demonstrated to have the ability to provide bone marrow niches. Moreover, the results of an investigation using a murine model of coronary vasculitis to confirm the anti-inflammatory effect of murine ADSC revealed anti-inflammatory effects and immune regulatory functions such as inhibition of inflammatory cytokines and reduction of the area of vasculitis; data useful for future elucidation of the mechanism of bone marrow reconstruction were obtained.
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Report
(5 results)
Research Products
(3 results)
