Analysis of drug-resistant mechanism in nephroblastoma with WTX abnormality
Project/Area Number |
26461600
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Research Institute for Clinical Oncology, Saitama Cancer Center |
Principal Investigator |
Masayuki Haruta 埼玉県立がんセンター(臨床腫瘍研究所), 臨床腫瘍研究所, 研究員 (80392190)
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Research Collaborator |
Kaneko Yasuhiko 埼玉県立がんセンター, 臨床腫瘍研究所, 参与
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 腎芽腫 / WTX |
Outline of Final Research Achievements |
In nephroblastoma, identification of new prognostic markers for better therapy planning are needed to improve the mortality and recurrence rate, and prevent side and late effects. We previously showed that WTX abnormality in nephroplastoma were correlated with poor prognosis in Japanese nephroplastoma. Some of nephroblastoma patients are long-term survive without relapse. In nephroblastoma with WTX abnormality, we performed SNP array analysis to clarify chromosomal abnormalities correlated with cancer death in 27 nephroblastoma with WTX abnormality. We couldn't identify chromosomal abnormalities correlated specifically with cancer death or event free. We have been performing comprehensive gene expression analysis for identification of signal pathway correlated with therapy resistance in nephroblastoma with WTX abnormality.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] A high incidence of WT1 abnormality in bilateral Wilms tumours in Japan, and the penetrance rates in children with WT1 germline mutation.2015
Author(s)
Kaneko Y, Okita H, Haruta M, Arai Y, Oue T, Tanaka Y, Horie H, Hinotsu S, Koshinaga T, Yoneda A, Ohtsuka Y, Taguchi T, Fukuzawa M.
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Journal Title
Br J Cancer
Volume: 112
Issue: 6
Pages: 1121-1133
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Management of pediatric renal tumor: Past and future trials of the Japan Wilms Tumor Study Group.2015
Author(s)
Oue T, Fukuzawa M, Koshinaga T, Okita H, Nozaki M, Chin M, Kaneko Y, Tanaka Y, Haruta M, Tsuchiya K, Kuwashima S, Takimoto T.
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Journal Title
Pediatr Int.
Volume: 57
Issue: 5
Pages: 828-31
DOI
Related Report
Peer Reviewed
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[Presentation] Trisomy 12 occurs before alteration of IGF2 expression and predicts favorable outcome in patients with Wilms tumors.2016
Author(s)
Kaneko Y, Haruta M, Kamijo T, Arai Y, Okita H, Tanaka T, Takimoto H, Nakadate H, Oue T, Nozaki M, M Chin, Koshinaga T, Fukuzawa M.
Organizer
48th Annual Congress of the International Society of Paediatric Oncology.
Place of Presentation
Dublin
Year and Date
2016-10-19
Related Report
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[Presentation] Relationships between genetic and chromosomal alterations and outcomes in Japanese Wilms tumor patients2015
Author(s)
春田雅之, 大島淳二郎, 新井康仁, 大喜多肇, 大植孝治, 田中祐吉, 野崎美和子, 瀧本哲也, 越永従道, 福澤正洋, 上條岳彦, 金子安比古
Organizer
第57回日本小児血液・がん学会学術集会
Place of Presentation
甲府富士屋ホテル
Year and Date
2015-11-27
Related Report
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