Morphological diagnosis of injured podocytes in various renal diseases with proteinuria by low vacuum scanning electron microscopy
Project/Area Number |
26461610
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Tottori University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
INAGA Sumire 鳥取大学, 医学部, 助教 (60116358)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 蛋白尿 / 糸球体上皮細胞 / 低真空走査型電子顕微鏡 / 糸球体基底膜 / シクロスポリン / アルポート症候群 / 菲薄基底膜病 |
Outline of Final Research Achievements |
We observed renal biopsy paraffin sections of various renal diseases patients by low vacuum scanning electron microscopy (LVSEM). The glomerular basement membranes showed characteristic coarse meshwork appearances in AS, and thin and sheet-like appearances in TBMN. Cyclosporin improved changes of foot processes of podocytes and alterations of podocytes cell bodies. Round-shaped podocytes cell bodies possibly represent injuries of podocytes in various renal diseases.
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Report
(4 results)
Research Products
(6 results)