clarification of the mechanism of proteinuria related with tranport protein

• Project/Area Number: 26461611
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Okayama University
• Principal Investigator: AYA KUNIHIKO 岡山大学, 医学部, 客員研究員 (20379762)
• Co-Investigator(Kenkyū-buntansha): 大内田 守 岡山大学, 医歯薬学総合研究科, 准教授 (80213635) ; 岡 剛史 岡山大学, 医歯薬学総合研究科, 講師 (50160651)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 細胞・組織 / 輸送蛋白 / 蛋白尿 / 尿細管 / 異形腺管 / ポドシン / 消化管 / 体重増加不良

Outline of Final Research Achievements

Though we induced proteinuria the podocyte-specific conditional knockout mice of this transport protein with LPS, we could not find strong tendency of the degree of albuminuria in knockout mice compared with control. We created the tamoxifen-inducible knockout mice of this transport protein. After tamoxifen administration, poor weight gain and atypical glands in intestine was found in these knockout mice.