Molecular mechanisms of the left-right axis malformations in pregnancy hyperglycemia
| Project/Area Number |
26461637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 糖尿病 / 左右軸 / 先天異常 / 高血糖 / 左右軸形成 / マウス初期胚 |
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| Outline of Final Research Achievements |
We concluded that the embryonic left-right asymmetry disorders due to the pregnancy diabetes is caused by hyperglycemia. The exposure to high glucose levels decreases Nodal and Cerl2 expression in the perinodal cells, and subsequent downregulation of Nodal expression in the left LPM.
We hypothesized that Wnt signaling is required for the primary determination of left-right axis in the node, and identified of the enhancer region of Wnt3a gene promoter and the enhancer binding protein for Wnt3a expression in the PS.
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Report
(5 results)
Research Products
(4 results)
