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Molecular mechanisms of the left-right axis malformations in pregnancy hyperglycemia

Research Project

Project/Area Number 26461637
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionKyushu University

Principal Investigator

Kitajima Keiko  九州大学, 医学研究院, 助教 (00332784)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords糖尿病 / 左右軸 / 先天異常 / 高血糖 / 左右軸形成 / マウス初期胚
Outline of Final Research Achievements

We concluded that the embryonic left-right asymmetry disorders due to the pregnancy diabetes is caused by hyperglycemia. The exposure to high glucose levels decreases Nodal and Cerl2 expression in the perinodal cells, and subsequent downregulation of Nodal expression in the left LPM.
We hypothesized that Wnt signaling is required for the primary determination of left-right axis in the node, and identified of the enhancer region of Wnt3a gene promoter and the enhancer binding protein for Wnt3a expression in the PS.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins.2016

    • Author(s)
      Ishii Y, Saeki K, Liu M, Sasaki F, Koga T, Kitajima K, Meno C, Okuno T, Yokomizo T
    • Journal Title

      FASEB J

      Volume: 30 Issue: 2 Pages: 933-947

    • DOI

      10.1096/fj.15-279653

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hyperglycemia impairs left-right axis formation and thereby disturbs heart morphogenesis in mouse embryos.2015

    • Author(s)
      Hachisuga M, Oki S, Kitajima K, Ikuta S, Sumi T, Kato K, Wake N, Meno C.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 112 Issue: 38 Pages: 5300-5307

    • DOI

      10.1073/pnas.1504529112

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 高血糖がマウス胚の左右軸形成に及ぼす影響2017

    • Author(s)
      目野主税、蜂須賀正紘、鄒兆南、沖真弥、北島桂子
    • Organizer
      日本先天異常学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高血糖症はマウス胚の左右軸形成を阻害することで心臓形態形成を撹乱する2014

    • Author(s)
      蜂須賀正紘、沖真弥、北島桂子、角智行、目野主税
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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