| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We concluded that the embryonic left-right asymmetry disorders due to the pregnancy diabetes is caused by hyperglycemia. The exposure to high glucose levels decreases Nodal and Cerl2 expression in the perinodal cells, and subsequent downregulation of Nodal expression in the left LPM.
We hypothesized that Wnt signaling is required for the primary determination of left-right axis in the node, and identified of the enhancer region of Wnt3a gene promoter and the enhancer binding protein for Wnt3a expression in the PS.
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