Glutamate Promotes Contraction of the Rat Ductus Arteriosus

• Project/Area Number: 26461639
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Yokohama City University
• Principal Investigator: FUJITA Shujiro 横浜市立大学, 医学研究科, 共同研究員 (90381516)
• Co-Investigator(Kenkyū-buntansha): 横山 詩子 横浜市立大学, 医学部, 准教授 (70404994)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 動脈管開存症 / グルタミン酸 / アミノ酸 / 動脈管 / 早産児

Outline of Final Research Achievements

Patent ductus arteriosus is a frequent and serious disease affecting the life and developmental prognosis of premature infants, but the influence of amino acids on the closure of the ductus arteriosus has not been clarified so far. This study revealed that glutamate induces rat ductus arteriosus contraction due to noradrenaline production. Administration of glutamate may be useful for prevention of patent ductus arteriosus in human premature infants.

Research Products

• [Journal Article] Glutamate Promotes Contraction of the Rat Ductus Arteriosus (2016)
  • Author(s): S. Fujita, U. Yokoyama, R. Ishiwata, R. Aoki, K. Nagao, D. Masukawa, M. Umemura, T. Fujita, S. Iwasaki, S. Nishimaki, K. Seki, S. Ito, Y. Goshima, T. Asou, M. Masuda, and Y. Ishikawa
  • Journal Title: Circulation Journal Volume: 80 Issue: 11 Pages: 2388-2396
  • DOI: 10.1253/circj.CJ-16-0649
  • NAID: 130005433144
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access