| Project/Area Number |
26461647
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
Ogawa Masaki 東京女子医科大学, 医学部, 教授 (50312707)
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| Co-Investigator(Kenkyū-buntansha) |
松井 英雄 東京女子医科大学, 医学部, 教授 (70190395)
金野 潤 東京女子医科大学, 医学部, 助教 (80722652)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 常位胎盤早期剥離 / メチル化 / SNP / 周産期死亡 / メチル化解析 / SNP解析 / 脱メチル化 / MMP-1 |
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| Outline of Final Research Achievements |
Genome-wide methylation and SNP analysis was carried out to prediction of placental abruption. Placental DNA from abruption was assayed, and then some specific methylated genes were identified, however, any SNP detected abruption was not identified. In placental abruption, gene methylation in placental DNA has been responsible for its onset.
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