Establishment of the novel embryonic cure system for an intractable skin disease mouse model by using a mesenchymal stem cells from the circulation blood of mouse embryo

• Project/Area Number: 26461681
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: University of Fukui
• Principal Investigator: Chino Takenao 福井大学, 学術研究院医学系部門, 助教 (20521397)
• Co-Investigator(Renkei-kenkyūsha): Hasegawa Minoru 福井大学, 学術研究院医学系部門, 教授 (50283130) ; Tokuriki Atsushi 福井大学, 学術研究医学系部門, 講師 (90397274)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: マウス胎仔治療 / 遺伝子治療 / 間葉系幹細胞 / 末梢血液 / マウス胎仔

Outline of Final Research Achievements

The purpose of this study is to establish the new system which collects the mesenchymal stem cells in the blood of the mouse embryo period, and the new cure system by giving these cells to an intractable skin disease mouse model. In this study, we analyzed the embryonic and neonatal skin of the new Dermokine β/γ knockout mouse in detail.