Elucidation of ultraviolet radiation-induced physiological degradation pathway of eumelanin and pheomelanin and its physiological significance
| Project/Area Number |
26461705
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Fujita Health University |
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Principal Investigator |
ITO Shosuke 藤田保健衛生大学, その他部局等, 名誉教授 (70121431)
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| Co-Investigator(Kenkyū-buntansha) |
若松 一雅 藤田保健衛生大学, 保健学研究科, 教授 (80131259)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メラニン / 紫外線 / ユーメラニン / フェオメラニン / UVA |
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| Outline of Final Research Achievements |
Melanin is classified into black eumelanin and reddish pheomelanin. Our study aimed at elucidating UVA(and blue light)-induced degradation of both melanins and its physiological significance. Using DHICA-melanin as a model of eumelanin, we showed that it is oxidized by UVA to form a quinone form and further oxidized to form a specific degradation product. We also showed that during these processes, superoxide radical and singlet oxygen are produced. We then showed that upon irradiation of 300-550 nm light, synthetic eumelanin and pheomelanin produce those reactive oxygen species which are rapidly trapped by melanin.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Identification of shell colour pigments in marine snails Calculus pharaonius and C. margaritarius (Trochoidea; Gastropoda)2016
Author(s)
ST Williams, S Ito, K Wakamatsu, T. Goral, NP Edwards, RA Wogelius, T Henkel, LFC de Oliveira, LF Maia, S Strekopytov, T Jeffries, DI Speiser, JT Marstin
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Journal Title
PLOS ONE
Volume: 11
Pages: 1-25
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Elemental characterization of melanin in feathers via synchrotron X-ray imaging and absorption spectroscopy2016
Author(s)
NP Edwords, A van Veelen, J Anne, PL Manning, U Bergmann, WI Sellers, VM Egerton, D Sokoras, R, Anoso-Mori, K Wakamatsu, S Ito, RA Wogelius
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] An insect with selective control of egg coloration.2015
Author(s)
Abram, P. K., Guerra-Grenier, E., Després-Einspenner, M-L., Ito, S., Wakamatsu, K., Boivin, G., Brodeur, J.
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Journal Title
Curr. Biol.
Volume: 25
Issue: 15
Pages: 2007-2011
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus.2015
Author(s)
Wakamatsu, K., Tabuchi, K., Ojika, M., Zucca, F. A., Zecca, L., Ito, S.
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Journal Title
J. Neurochem.
Volume: 135
Issue: 4
Pages: 768-776
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Mineralized rods and cones suggest colour vision in a 300 Myr-old fossil fish2014
Author(s)
Tanaka, G., Parker, A.R., Hasegawa, Y., Siveter, D.J., Yamamoto, R., Miyashita, K., Takahashi, Y., Ito, s., Wakamatsu, K., Mukuda, T., Matsuura, M., Tomikawa, K., Furutani, M., Suzuki, K., and Maeda, H.
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Journal Title
Nature Communications
Volume: 5
Issue: 1
Pages: 5920-5920
DOI
NAID
Related Report
Peer Reviewed
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