Change in metabolites and transgenerational effects after rearrangement of brain DNA methylation
| Project/Area Number |
26461711
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | DNAメチル化 / エピジェネティクス / 恐怖条件付け / 次世代 |
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| Outline of Final Research Achievements |
DNA methylation is a kind of gene expression control system with no change in the genome. In this study, methyl donor deficient diet was used to rearrangement of DNA methylation in the brain of mice during 3wk to 6wk of age after weaning. The author investigated the effect of the diet on the behavior and gene expression and change of metabolites in the hippocampus, and also those alterations int the next generation. As a result, F1 mice which has the father wit methyl deficient diet history showed different behaviors especially in the fear conditioning and extinction paradigm and gene expressions and metabolites changes in the hippocampus compared to the control mice. The results suggest that the alteration in the brain DNA methylation affects behaviors, gene expressions, and metabolites in the next generation.
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Report
(5 results)
Research Products
(12 results)
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[Presentation] 不安とエピジェネティクス2015
Author(s)
松澤大輔
Organizer
第57回日本心身医学会学術講演会
Place of Presentation
タワーホール船堀(東京都江戸川区)
Year and Date
2015-06-26
Related Report
Invited
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