NrCAM develops brain neural network and behavioral phenotypes of addiction.
Project/Area Number |
26461716
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
|
Research Institution | University of Yamanashi |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | NrCAM / 脳神経ネットワーク / グルタミン酸神経 / GABA神経 / ドパミン神経 / 覚せい剤依存 / コカイン依存 / 依存 / 神経接着因子 / メタンフェタミン / コカイン / 物質依存 / グルタミン酸 / GABA / 神経ネットワーク / 神経細胞接着因子 / マイクロアレイ |
Outline of Final Research Achievements |
Substance dependence shows certain behavioral characteristics, such as novelty seeking sociability, obsessiveness, depression and anxiety besides preference. However, there is no medicine developed by understanding of the disease. Our previous study evaluated NrCAM that works in vulnerability to addiction. We therefore evaluated several neural molecules that changed their gene expression by methamphetamine administration, in addition, differently by low Nrcam expression. Among those, 5 genes were differently changed their expression also by cocaine administration in mice. Those glutaminergic, GABAergic, dopaminergic molecules could be new therapeutic targets for substance non-specific addiction.
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Report
(4 results)
Research Products
(8 results)