| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Substance dependence shows certain behavioral characteristics, such as novelty seeking sociability, obsessiveness, depression and anxiety besides preference. However, there is no medicine developed by understanding of the disease. Our previous study evaluated NrCAM that works in vulnerability to addiction. We therefore evaluated several neural molecules that changed their gene expression by methamphetamine administration, in addition, differently by low Nrcam expression. Among those, 5 genes were differently changed their expression also by cocaine administration in mice. Those glutaminergic, GABAergic, dopaminergic molecules could be new therapeutic targets for substance non-specific addiction.
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