Impairments in social bonding by PTSD
| Project/Area Number |
26461734
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Gunma University |
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Principal Investigator |
Mitsui Shinichi 群馬大学, 大学院保健学研究科, 教授 (20295661)
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| Co-Investigator(Kenkyū-buntansha) |
高橋 麻衣子 (池澤麻衣子) 群馬大学, 大学院保健学研究科, 助教 (50701322)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | プレリーハタネズミ / pair bonding / オキシトシン / セロトニン / 恐怖記憶 / social buffering / Prairie vole / SON / PVN / 絆 / ストレス / バソプレッシン / パロキセチン / 視索上核 / 室傍核 |
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| Outline of Final Research Achievements |
There are some reports indicating that post-tramatic stress disorder (PTSD) disrupt the social relationship between intimates. To understand the neuronal mechanisms of such phenominon, we have investigated the effect of traumatic stress on social behaviors and neuronal responses in monogamous prairie voles. Traumatic stress decreased the oxytosin-immunoreactivity at the supraoptic nucleus of thy hypothalamus and impaired the fomotion of pair bonding. The inhibitory effect by a traumatic stress was prevented by oral administration of a selective serotonin reuptake inhibitor.
Our results have revealed the impairment of social behviors and neuronal circuits caused by PTSD and will give a basic knowledge to develop novel treatment of PTSD.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles.2016
Author(s)
1.Arai, A., Hirota, Y., Miyase, N., Miyata, S., Young, L. J., Osako, Y., Yuri, K., *Mitsui, S.
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Journal Title
Behavioural Brain Research
Volume: 315
Pages: 83-93
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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