Impairments in social bonding by PTSD

• Project/Area Number: 26461734
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: Mitsui Shinichi 群馬大学, 大学院保健学研究科, 教授 (20295661)
• Co-Investigator(Kenkyū-buntansha): 高橋 麻衣子 (池澤麻衣子) 群馬大学, 大学院保健学研究科, 助教 (50701322)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: プレリーハタネズミ / pair bonding / オキシトシン / セロトニン / 恐怖記憶 / social buffering / Prairie vole / SON / PVN / 絆 / ストレス / バソプレッシン / パロキセチン / 視索上核 / 室傍核

Outline of Final Research Achievements

There are some reports indicating that post-tramatic stress disorder (PTSD) disrupt the social relationship between intimates. To understand the neuronal mechanisms of such phenominon, we have investigated the effect of traumatic stress on social behaviors and neuronal responses in monogamous prairie voles. Traumatic stress decreased the oxytosin-immunoreactivity at the supraoptic nucleus of thy hypothalamus and impaired the fomotion of pair bonding. The inhibitory effect by a traumatic stress was prevented by oral administration of a selective serotonin reuptake inhibitor.
Our results have revealed the impairment of social behviors and neuronal circuits caused by PTSD and will give a basic knowledge to develop novel treatment of PTSD.

Research Products

• [Int'l Joint Research] Emory University School of Medicine(米国)
• [Int'l Joint Research] エモリー大学(米国)
• [Journal Article] A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles. (2016)
  • Author(s): 1.Arai, A., Hirota, Y., Miyase, N., Miyata, S., Young, L. J., Osako, Y., Yuri, K., *Mitsui, S.
  • Journal Title: Behavioural Brain Research Volume: 315 Pages: 83-93
  • DOI: 10.1016/j.bbr.2016.08.022
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Tissue plasminogen activator modulates emotion in a social context (2015)
  • Author(s): Kazuki Nakamura, Ayumi Takabe, Fuki Shimizu, Maiko Takahashi, Osamu Matsuo, Shinichi Mitsui
  • Journal Title: Behavioral Brain Research Volume: 281 Pages: 24-31
  • DOI: 10.1016/j.bbr.2014.11.022
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Disturbance of the maintenance of pair bond by traumatic stresses in monogamous prairie voles. (2016)
  • Author(s): 廣田 湧，吉澤 萌香，石澤 美衣，佐藤 葵 ，民部 由莉，由利 和也，三井 真一
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Effects of traumatic stresses on brain region for pair bonding in prairie voles, a monogamous rodent. (2016)
  • Author(s): 新井 亜紀，廣田 湧，三井 真一
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Motopsin/PRSS12 and seizure related gene (sez) -6 individually enhance neurite development in PC12 cells. (2016)
  • Author(s): 茂原 美穂，三井 真一
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] プレリーハタネ ズミの雌雄の絆（pair bond）はsingle prolonged stress（SPS）によって破綻する (2015)
  • Author(s): 廣田 湧、吉澤 萌香、石澤 美衣;、佐藤 葵、民部 由莉、由利 和也、三井 真一
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-03
• [Presentation] 細胞形態の調節においてのsez-6のN型糖鎖の役割 (2015)
  • Author(s): 日高 千晴、三井 真一
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-01
• [Presentation] Role of N-glycans to a function of a trans-membrane protein, seizure-related gene 6 (sez-6). (2015)
  • Author(s): Chiharu Hidaka, Shinichi Mitsui
  • Organizer: 第58回日本神経化学学会大会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2015-09-13
• [Presentation] パロキセチンはSingle prolonged stressによって阻害されたプレリーハタネズミのつがい形成を復元する (2015)
  • Author(s): 新井 亜紀、廣田 湧、吉澤 萌香、石澤 美衣 、佐藤 葵、民部 由莉、Young J Larry、大迫 洋治、由利 和也 、三井 真一
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-07-30
• [Presentation] 一夫一婦制げっ歯類におけるパートナーロスによる痛みの修飾 (2015)
  • Author(s): 大迫 洋治、西原 真理、信原 玲子、内田 有希、牛田 享宏、三井 真一、Young J Larry、由利 和也
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-07-30
• [Presentation] Seizure-related gene 6 (SEZ-6) modulates formation of filopodia-like protrusions. (2014)
  • Author(s): Chiharu Hidaka, Shinichi Mitsui
  • Organizer: 6th International Conference on Advanced Micro-Device Engineering
  • Place of Presentation: 桐生市
  • Year and Date: 2014-12-05
• [Presentation] A single prolonged stress disturbs pair bonding in the monogamous, prairie vole. (2014)
  • Author(s): Aki Arai, Yu Hirota, Shiori Miyata, Naoki Miyase, Larry Young, Yoji Osako, Kazunari Yuri, Shinichi Mitsui
  • Organizer: 第37回日本神経科学大会 Neuroscience 2014
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11 – 2014-09-13
• [Remarks] 群馬大学大学院保健学研究科リハビリテーション学講座・三井研究室
  • URL: http://mitsuilab.health.gunma-u.ac.jp