Neuropathology of Schizophrenia focused on genetic background

• Project/Area Number: 26461742
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nagoya University
• Principal Investigator: Shuji Iritani 名古屋大学, 医学系研究科, 寄附講座教授 (60191904)
• Co-Investigator(Renkei-kenkyūsha): OZAKI Norio 名古屋大学, 大学院医学系研究科, 教授 (40281480) ; FUJISHIRO Hiroshige 名古屋大学, 大学院医学系研究科, 寄附講座講師 (20536924)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 統合失調症 / リスク遺伝子 / 死後脳 / 神経病理 / 神経ネットワーク / モデル動物

Outline of Final Research Achievements

The aim of this study is to disclose the neuropathological background of psychiatric illness including schizophrenia. It was especially focused the brains, which were well known the genetic background including the genetic modified model mouse (DISC1 KO mouse), Japanese monkey with lacking ABCA13 gene (autism model mouse) and postmortem human brains (GLO1 frame shift, 22q11 deletion syndrome, MBD5 deletion syndrome). Brains were investigated by neuropathological approach including classical staining such as H.E. stain and Nissle stain and GABAergic or Catecholaminergic neuronal network using immunohistochemical techniques. As the results, some cytoarchitectual abnormality or impairment of neuronal networks, deficiency of migration of neurons were observed in each individual. Those phenomena seemed to indicate one of the pathogenesis of psychiatric illness and the interaction of each genetic action and pathological phenotype.

Research Products

• [Journal Article] Bright light therapy for sleep disturbance in dementia is most effective for mild to moderate Alzheimer's type dementia: a case series. (2017)
  • Author(s): Sekiguchi H, Iritani S, Fujita K.
  • Journal Title: Psychogeriatrics Volume: 印刷中 Issue: 5 Pages: 275-281
  • DOI: 10.1111/psyg.12233
  • Peer Reviewed
• [Journal Article] Neuropeptide Y neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia. (2017)
  • Author(s): Morosawa S, Iritani S, Fujishiro H, Sekiguchi H, Torii Y, Habuchi C, Kuroda K, Kaibuchi K, Ozaki N
  • Journal Title: Neuropeptides Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An autopsy case of dementia with Lewy bodies clinically diagnosed to have a behavioral variant of frontotemporal dementia. (2017)
  • Author(s): Sekiguchi H, Moriwaki M, Iritani S, Habuchi C, Torii Y, Umeda K, Fujishiro H, Yoshida M, Fujita K.
  • Journal Title: Clin Neuropathol Volume: 36 Issue: 01 Pages: 23-30
  • DOI: 10.5414/np300869
  • Peer Reviewed
• [Journal Article] Delirium prior to dementia as a clinical phenotype of Lewy body disease: an autopsied case report. (2017)
  • Author(s): Fujishiro H, Kawakami I, Oshima K, Niizato K, Iritani S.
  • Journal Title: Int Psychogeriatr Volume: 79 Issue: 4 Pages: 687-689
  • DOI: 10.1017/s1041610216001265
  • Peer Reviewed
• [Journal Article] REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series (2017)
  • Author(s): Fujishiro H, Okuda M, Iwamoto K, Miyata S, Otake H, Noda A, Iritani S, Ozaki N. T.
  • Journal Title: Int J Geriatr Psychiatry Volume: 32 Issue: 4 Pages: 397-406
  • DOI: 10.1002/gps.4477
  • Peer Reviewed
• [Journal Article] High-resolution copy number variation analysis of schizophrenia in Japan. (2017)
  • Author(s): Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T,
  • Journal Title: Molecular Psychiatry Volume: 22 Issue: 3 Pages: 430-440
  • DOI: 10.1038/mp.2016.88
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Immunohistochemical evaluation of the GABAergic neuronal system in the prefrontal cortex of a DISC1 knockout mouse model of schizophrenia (2016)
  • Author(s): Umeda K, Iritani S, Fujishiro H, Sekiguchi H, Torii Y, Habuchi C, Kuroda K, Kaibuchi K, Ozaki N.
  • Journal Title: Synapse Volume: 70 Issue: 12 Pages: 508-518
  • DOI: 10.1002/syn.21924
  • Peer Reviewed
• [Journal Article] An autopsy case of cortical superficial siderosis with persistent abnormal behavior. (2016)
  • Author(s): Torii Y,Iritani S, Fujishiro H, Sekiguchi H, Habuchi C, Umeda K, Matsunaga S, Mimuro M, Ozaki N, Yoshida M, Fujita K.
  • Journal Title: Neuropathology Volume: 36 Issue: 6 Pages: 544-550
  • DOI: 10.1111/neup.12301
  • NAID: 120005981228
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Catecholaminergic neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia (2016)
  • Author(s): Shuji Iritani, Hirotaka Sekiguchi, Chikako Habuchi, Youta Torii, Keisuke Kuroda, Kozo Kaibuchi and Norio Ozaki
  • Journal Title: Acta Neuropsychiatrica Volume: 28 Issue: 2 Pages: 117-123
  • DOI: 10.1017/neu.2015.51
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Crosstalk with psychiatry and neurology : how to treat “somatic symptom and related disorder” (2016)
  • Author(s): 入谷修司
  • Journal Title: Neurological Therapeutics Volume: 33 Issue: 3 Pages: 409-412
  • DOI: 10.15082/jsnt.33.3_409
  • NAID: 130005279037
  • ISSN: 0916-8443, 2189-7824
• [Journal Article] Hypochondriasis as early manifestation in dementia with Lewy bodies: an autopsied case report (2016)
  • Author(s): Fujishiro H, Iritani S, Sekiguchi H, Habuchi C, Torii Y, Matsunaga S, Ozaki N, Yoshida M, Fujita K.
  • Journal Title: Psychogeriatrics Volume: 16 Issue: 2 Pages: 139-144
  • DOI: 10.1111/psyg.12128
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 精神医学における神経病理学の重要性・再認識 (2016)
  • Author(s): 入谷修司
  • Journal Title: 老年精神医学雑誌 Volume: 27
• [Journal Article] Long-term efficacy of donepezil for relapse of visual hallucinations in patients with dementia with Lewy bodies. (2015)
  • Author(s): Ukai K, Fujishiro H, Iritani S, Ozaki N.
  • Journal Title: Psychogeriatrics Volume: 15 Issue: 2 Pages: 133-137
  • DOI: 10.1111/psyg.12089
  • Peer Reviewed
• [Journal Article] Assessment of copy number variations in the brain genome of schizophrenia patients. (2015)
  • Author(s): Sakai M, Watanabe Y, Someya T, Araki K, Shibuya M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Hashimoto T, Hishimoto A, Kitamura N, Iritani S, Shirakawa O, Maeda K, Miyashita A, Niwa S, Takahashi H, Kakita A, Kuwano R, Nawa H.
  • Journal Title: Mol Cytogenet. Volume: 8 Issue: 1 Pages: 46-46
  • DOI: 10.1186/s13039-015-0144-5
  • Peer Reviewed / Open Access
• [Journal Article] Autopsy-confirmed hippocampal-sparing Alzheimer’s disease with delusional jealousy as initial manifestation. (2015)
  • Author(s): Fujishiro H, Iritani S, Hattori M, Sekiguchi H, Matsunaga S, Habuchi C, Torii Y, Umeda K, Ozaki N, Yoshida M, Fujita K.
  • Journal Title: Psychogeriatrics Volume: 15 Issue: 3 Pages: 198-203
  • DOI: 10.1111/psyg.12105
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The effects of acute treatment with ramelteon, triazolam, and placebo on driving performance, cognitive function, and equilibrium function in healthy volunteers. (2015)
  • Author(s): Miyata A, Iwamoto K, Kawano N, Kohmura K, Yamamoto M, Aleksic B, Ebe K, Noda A, Noda Y, Iritani S, Ozaki N.
  • Journal Title: Psychopharmacology (Berl). Volume: 12 Issue: 12 Pages: 2127-37
  • DOI: 10.1007/s00213-014-3843-4
  • Peer Reviewed
• [Journal Article] 患者自身のための抗認知症薬の効果と適応 (2015)
  • Author(s): 入谷修司
  • Journal Title: 老年精神医学雑誌 Volume: 26
• [Journal Article] 21世紀のブレインバンク : その運営と研究応用 (2014)
  • Author(s): 入谷修司
  • Journal Title: 日本生物学的精神医学会誌 Volume: 25 Pages: 139-142
  • NAID: 130005395546
• [Journal Article] 高齢発症の統合失調症 (2014)
  • Author(s): 諸沢 俊介,小出 隆義,入谷 修司
  • Journal Title: 精神科 Volume: 25 Pages: 440-444
  • Peer Reviewed
• [Presentation] 身体症状症とレビー小体病 REM sleep without atoniaの定量評価について (2016)
  • Author(s): 岡田 一平、藤城弘樹、奥田将人、横井珠希、小出みあ、木村宏之、岩本邦弘、鳥居 洋太、入谷 修司、尾崎 紀夫
  • Organizer: 第35回日本認知症学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-12-01
• [Presentation] 名古屋大学精神科コンソーシアムブレインバンクにおける嗜銀顆粒病の出現頻度と臨床像 (2016)
  • Author(s): 平野 光彬、三輪 綾子、鳥居洋太、関口 裕孝、羽渕 知可子、藤城 弘樹、入谷 修司、尾崎紀夫、吉田眞理、藤田潔
  • Organizer: 第35回日本認知症学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-12-01
• [Presentation] Lewy小体病の鑑別における神経画像検査の有用性について (2016)
  • Author(s): 玉越 悠也、藤城 弘樹、鳥居 洋太、岩本 邦弘、入谷 修司、尾崎 紀夫
  • Organizer: 第31回日本老年精神医学会
  • Place of Presentation: 金沢歌劇座(石川県金沢市）
  • Year and Date: 2016-06-23
• [Presentation] 不安症が先行したパーキンソン病の2症例 (2016)
  • Author(s): 三輪 綾子, 藤城 弘樹, 鳥居 洋太, 入谷 修司, 尾崎 紀夫
  • Organizer: 第31回日本老年精神医学会
  • Place of Presentation: 金沢歌劇座(石川県金沢市）
  • Year and Date: 2016-06-23
• [Presentation] 統合失調症の長期経過中に認知機能低下と激しい易怒性を呈した一剖検例 (2016)
  • Author(s): 平野光彬、三輪綾子、鳥井洋太、関口裕孝、羽渕知可子、藤城弘樹、入谷修司、尾崎紀夫、吉田眞理、藤田潔
  • Organizer: 第31回日本老年精神医学会
  • Place of Presentation: 金沢歌劇座(石川県金沢市）
  • Year and Date: 2016-06-23
• [Presentation] 精神科とのクロストーク (2015)
  • Author(s): 入谷 修司
  • Organizer: 第33回日本神経治療学会総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市)
  • Year and Date: 2015-11-26
  • Invited
• [Presentation] The neuropathological study of Myeline-Oligodendrocyte in postmortem schizophrenic brain (2015)
  • Author(s): T.Marui, S.Iritani, Y.Torii, S.Morosawa,K.Umeda, H. Sekiguchi ,C. Habuchi, H.Fujishiro, K.Oshima, K.Niizato, K.Masaki, J.Kira & N.Ozaki
  • Organizer: 5th European Conference on Schizophrenia Research
  • Place of Presentation: ベルリン、ドイツ
  • Year and Date: 2015-09-24
  • Int'l Joint Research
• [Presentation] Distribution of neuropeptide Y in the frontal cortex of, a model mouse of schizophrenia, DISC1 knockout mouse: (2015)
  • Author(s): Shunsuke Morosawa, Shuji Iritani, Tomoyasu Marui, Kentaro Umeda, Hirotaka Sekiguchi, Chikako Habuchi, Yota Torii, Fujishiro Hirotaka, Keisuke Kuroda, Kozo kaibuchi, Norio Ozaki
  • Organizer: 5th European Conference on Schizophrenia Research
  • Place of Presentation: ベルリン、ドイツ
  • Year and Date: 2015-09-24
  • Int'l Joint Research
• [Presentation] 過活動型せん妄の改善後、異常行動が遷延した脳表ヘモジデローシスの一剖検例 (2015)
  • Author(s): 鳥居 洋太, 入谷修司, 藤城 弘樹, 梅田 健太郎, 藤田 潔, 関口 裕孝, 羽渕 知可子, 三室 マヤ, 辰己 新水, 岩崎 靖, 吉田 眞理
  • Organizer: 第30回日本老年精神医学会
  • Place of Presentation: 横浜パシフィコ(神奈川県横浜市）
  • Year and Date: 2015-06-12
• [Presentation] 統合失調症死後脳上側頭回における抗Myelin-Oligodendrocyte-Glycoprotein(MOG)抗体による免疫組織学的検討 (2015)
  • Author(s): 丸井友泰，鳥居洋太、大島健一、新里和弘、眞崎勝久、吉良潤一、藤城弘樹、入谷修司、尾崎紀夫
  • Organizer: 第10回日本統合失調症学会
  • Place of Presentation: 都市センターホテル（東京都千代田区）
  • Year and Date: 2015-03-27 – 2015-03-28
• [Presentation] TWO AUTOPSY CASES OF DLB PRESENTING PROLONGED REFRACTORY DELIRIUM IN CLINICAL COURSE (2015)
  • Author(s): Shuji IRITANI, Hiroshige FUJISHIRO、Hirotaka SEKIGUCHI, Chikako HABUCHI, Kenichi OSHIMA, Kazuhiro NIIZATO
  • Organizer: 12th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Nice (France)
  • Year and Date: 2015-03-18 – 2015-03-22
• [Presentation] 身体不定愁訴を認めた78歳男性の1剖検例 レビー小体型認知症の初期症状について (2014)
  • Author(s): 藤城 弘樹, 入谷 修司, 関口 裕孝, 松永 慎史, 羽渕 知可子, 鳥居 洋太, 梅田 健太郎, 尾崎 紀夫, 吉田 眞理, 藤田 潔
  • Organizer: 第33回日本認知症学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2014-11-29 – 2014-12-01
• [Presentation] 物盗られ妄想を認めた頭部外傷後器質性精神障害の神経画像所見 (2014)
  • Author(s): 関口 裕孝), 入谷 修司, 藤田 潔
  • Organizer: 第29回日本老年精神医学会
  • Place of Presentation: 日本教育会館(東京都千代田区）
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] 解剖データから見た老年期精神障害； 連続剖検記録を基にした解析 (2014)
  • Author(s): 内山 裕之, 新里 和弘, 厚東 知成, 河上 緒, 大島 健一, 入谷 修司, 齋藤 正彦
  • Organizer: 第29回日本老年精神医学会
  • Place of Presentation: 日本教育会館(東京都千代田区）
  • Year and Date: 2014-06-12 – 2014-06-13
• [Book] 認知症などの器質性疾患の前触れとしてのうつ病・うつ状態 (2016)
  • Author(s): 関口裕孝、入谷修司
  • Total Pages: 152
  • Publisher: 医薬ジャーナル
• [Remarks] 名古屋大学大学院医学系研究科
  • URL: https://www.med.nagoya-u.ac.jp/seisin/
• [Remarks] 名古屋大学精神科ホームページ
  • URL: http://www.med.nagoya-u.ac.jp/seisin/