Elucidation of neuroscientific basis on cognitive behavioral therapy

• Project/Area Number: 26461748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hiroshima University
• Principal Investigator: Okamoto Yasumasa 広島大学, 医歯薬保健学研究院(医), 准教授 (70314763)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 認知行動療法 / うつ病 / 神経科学 / MRI / fMRI / サイバーボール課題

Outline of Final Research Achievements

We used functional magnetic resonance imaging (fMRI) to investigate neural activity associated with cognitive behavioral therapy (CBT). At first, cognitive reappraisals targeting the anxiety were associated with increased activity in the medial and lateral prefrontal regions (including the orbitofrontal and anterior cingulate cortices) and decreased fear circuit activity (including the amygdala and thalamus). Correlational analysis demonstrated that reductions in subjective anxiety associated with reappraisal were correlated with orbitofrontal and anterior cingulate cortex activation. CBT for depressive subjects results in improved functioning of the front-parietal region during loss anticipation during a monetary incentive delay task and also in increased dorsomedial PFC activation during other perspective self-referential processing with improvement of depressive symptoms.

Research Products

• [Journal Article] Effects of behavioral activation on the neural basis of other perspective self referential processing in subthreshold depression: An fMRI study. (2017)
  • Author(s): Shiota, S., Okamoto, Y., Okada, G., Takagaki, K., Takamura, M., Mori, A., Yokoyama, S., Nishiyama, Y., Jinnin, R., Hashimoto, R., & Yamawaki, S.
  • Journal Title: Psychological Medicine Volume: 47 Issue: 5 Pages: 877-888
  • DOI: 10.1017/s0033291716002956
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices. (2017)
  • Author(s): Yoshimura S, Okamoto Y, Matsunaga M, Onoda K, Okada G, Kunisato Y, Yoshino A, Ueda K, Suzuki SI, Yamawaki S.
  • Journal Title: J Affect Disord Volume: 208 Pages: 610-614
  • DOI: 10.1016/j.jad.2016.10.017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task. (2016)
  • Author(s): Mori A, Okamoto Y, Okada G, Takagaki K, Jinnin R, Takamura M, Kobayakawa M, Yamawaki S.
  • Journal Title: J Affect Disord. Volume: 189 Pages: 254-262
  • DOI: 10.1016/j.jad.2015.12.023
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] fMRI Study of Social Anxiety during Social Ostracism with and without Emotional Support. (2015)
  • Author(s): Nishiyama Y, Okamoto Y, Kunisato Y, Okada G, Yoshimura S, Kanai Y, Yamamura T, Yoshino A, Jinnin R, Takagaki K, Onoda K, Yamawaki S
  • Journal Title: PLoS One Volume: 10 Issue: 5 Pages: 0127426-0127426
  • DOI: 10.1371/journal.pone.0127426
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant