Cross sectional and longitudinal studies of bone fragility with clinical CT-based finite element analysis

• Project/Area Number: 26461792
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hiroshima University
• Principal Investigator: Takasu Miyuki 広島大学, 病院(医), 病院助教 (70565647)
• Co-Investigator(Kenkyū-buntansha): 黒田 芳明 自治医科大学, 医学部, 助教 (00625840) ; 粟井 和夫 広島大学, 医歯薬保健学研究院(医), 教授 (30294573) ; 中西 一義 広島大学, 病院(医), 講師 (60403557)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 続発性骨粗鬆症 / 多発性骨髄腫 / 有限要素法 / 多列検出器CT / 骨粗鬆症

Outline of Final Research Achievements

The prevalence of osteoporosis was significantly higher in post TACE patients than in control subjects. The cumulative radiation dose related to routine dynamic CT studies was a significant contributor to the prevalence of osteoporosis. MDCT demonstrated that bone strength and bone mass were not significantly reduced in patients who underwent ASCT compared with the bortezomib group. Osteoporosis does not appear to be a long-term complication of ASCT. Lenalidomide treatment resulted in significant increases in CT/FEM-derived estimates of bone strength. Response to chemotherapy predicted lenalidomide-induced bone changes and good responders had increased bone strength. The validation of MDCT against gold-standards CBCT suggests that indices of bone quality including BV/TV may be appropriate for clinical monitoring of bone quality by MDCT. Iterative reconstruction improved the correlation between 64-section MDCT and micro-CT-derived metric parameters.

Research Products

• [Journal Article] 1.エキスパートによるRSNA 2016ベストリポート領域別最新動向：CT＆MRIの技術と臨床を中心に 骨軟部 (2017)
  • Author(s): 高須深雪
  • Journal Title: INNERVISION Volume: 2
• [Journal Article] 多発性骨髄腫の画像診断 (2016)
  • Author(s): 高須深雪, 馬場康貴, 富士智世, 谷千尋, 坂井晃, 麻奥英毅, 一戸辰夫, 粟井和夫
  • Journal Title: 臨床画像 Volume: 10
• [Journal Article] 3.【多発性骨髄腫学-最新の診療と基礎研究-】 多発性骨髄腫の検査、診断 画像診断 MRI(解説/特集) (2016)
  • Author(s): Takasu T, Oshima K, Ichinohe T, Baba Y, Awai K
  • Journal Title: 日本臨牀 Volume: 74 Pages: 252-257
• [Journal Article] A longitudinal study of the prediction of pathologic spinal fractures in multiple myeloma with trabecular microarchitecture and CT-based finite element analyses. (2016)
  • Author(s): Takasu M, Tani T, Kaichi Y, et al.
  • Journal Title: Musculoskelet Disord Treat Volume: 2
  • Peer Reviewed
• [Journal Article] Trabecular bone changes in the spine after transarterial chemoembolization therapy for hepatocellular carcinoma (2015)
  • Author(s): Takasu M, Baba Y, Awai K
  • Journal Title: Clin Calcium Volume: 25 Pages: 1659-66
  • Int'l Joint Research
• [Journal Article] Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) magnetic resonance imaging as a biomarker for symptomatic multiple myeloma. (2015)
  • Author(s): Takasu M1, Kaichi Y1, Tani C1, Date S1, Akiyama Y1, Kuroda Y2, Sakai A3, Awai K1.
  • Journal Title: PLoS One Volume: 10 Issue: 2 Pages: 1-14
  • DOI: 10.1371/journal.pone.0116842
  • Peer Reviewed / Open Access
• [Journal Article] Multidetector computed tomography-based microstructural analysis reveals reduced bone mineral content and trabecular bone changes in the lumbar spine after transarterial chemoembolization therapy for hepatocellular carcinoma. (2014)
  • Author(s): Takasu M1, Yamagami T1, Nakamura Y1, Komoto D1, Kaichi Y1, Tani C1, Date S1, Kiguchi M1, Awai K1.
  • Journal Title: PLoS One Volume: 9 Issue: 10 Pages: e110106-e110106
  • DOI: 10.1371/journal.pone.0110106
  • Peer Reviewed / Open Access
• [Journal Article] A longitudinal computed tomography study of lenalidomide and bortezomib treatment for multiple myeloma: trabecular microarchitecture and biomechanics assessed using multidetector computed tomography. (2014)
  • Author(s): Takasu M1, Tani C2, Kaichi Y2, Sakoda Y3, Kiguchi M2, Date S2, Kuroda Y4, Sakai A5, Awai K2.
  • Journal Title: Clin Lymphoma Myeloma Leuk Volume: 14 Issue: 6 Pages: 485-92
  • DOI: 10.1016/j.clml.2014.07.009
  • Peer Reviewed / Open Access
• [Presentation] Effect of autologous stem cell transplant on bone mineral density and bone strength in patients with multiple myeloma (2016)
  • Author(s): Miyuki Takasu, Chikako Fujioka, Koumei Takauchi, Yasutaka Baba, Yoko Kaichi, Kazuo Awai, Masao Kiguchi, Chihiro Tani
  • Organizer: RSNA The 102th Scientific Assembly and Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-26
  • Int'l Joint Research
• [Presentation] Differentiation of Spinal Lesions Using Monoexponential, Biexponential, and Gamma Distribution Diffusion-Weighted MR Imaging: Initial Clinical Results (2016)
  • Author(s): Miyuki Takasu, Yuji Akiyama, Chihiro Tani, Yoko Kaichi, Takayuki Tamura, Koichi Oshio, Kazuo Awai
  • Organizer: ISMRM 24th Scientific Meeting And Exhibition
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Effect of iterative reconstruction algorithms on measurement of trabecular bone microstructure with clinical MDCT: a cadaver study using micro-CT as the reference standard (2016)
  • Author(s): Miyuki Takasu, Chikako Fujioka, Yoko Kaichi, Chihiro Tani, Masao Kiguchi, Nobuhito Nango, Masafumi Machida ,Kazuo Awai
  • Organizer: 第75回日本医学放射線学会学術発表会
  • Place of Presentation: 横浜
  • Year and Date: 2016-04-14
• [Presentation] 全身MRIとPETとの比較－多発性骨髄腫を中心に. (2016)
  • Author(s): 高須深雪
  • Organizer: 第2回Hematological imaging and therapeutic seminar
  • Place of Presentation: 大阪
  • Invited
• [Presentation] Vertebral bone marrow fat content measured by MRI associated with bone mineral density: a study in cadavers using micro-CT as the reference standard (2015)
  • Author(s): Miyuki Takasu, Yuji Akiyama, Ryuji Akita, Kazushi Yokomachi, Yoko Kaichi, Chihiro Tani, Masatoshi Honda, and Kazuo Awai
  • Organizer: Radiological Society of North America 101th annual meegint
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-11-27
  • Int'l Joint Research
• [Presentation] Effect of iterative reconstruction algorithms on measurement of trabecular bone microstructure with clinical MDCT: a cadaver study using micro-CT as the reference standard (2015)
  • Author(s): Miyuki Takasu, Chikako Fujioka, Yoko Kaichi, Chihiro Tani, Masao Kiguchi, Kazuo Awai, Nobuhito Nango, Masafumi Machida
  • Organizer: Radiological Society of North America 101th annual meegint
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-11-27
  • Int'l Joint Research
• [Presentation] Clinical application of gamma distribution model for spinal lesions: Initial clinical results (2015)
  • Author(s): Miyuki Takasu, Koichi Oshio, Yuji Akiyama, Ryuji Akita, Yoko Kaichi, Kazushi Yokomachi Shuji Date, Kazuo Awai
  • Organizer: International Society for Magnetic Resonance in Medicine 23th annual meeting
  • Place of Presentation: Toronto （Canada)
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Vertebral bone marrow fat content measured by MRI associated with lower bone mineral density: a human cadaver study (2015)
  • Author(s): Miyuki Takasu, Yuji Akiyama, Ryuji Akita, Kazushi Yokomachi, Masatoshi Honda, Yoko Kaichi, Shuji Date, Kazuo Awai
  • Organizer: International Society for Magnetic Resonance in Medicine 23th annual meeting
  • Place of Presentation: Toronto (USA)
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Predicting pathologic spine fracture in multiple myeloma patients using trabecular microarchitecture and CT-based finite element analysis: a longitudinal study (2015)
  • Author(s): M. Takasu, Y. Kaichi, C. Tani, S. Date, M. Kiguchi, Y. Kuroda, A. Sakai, K. Awai
  • Organizer: 第25回日本医学放射線学会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-16
• [Presentation] A longitudinal study of predicting pathologic spine fractures in multiple myeloma with trabecular microarchitecture and CT-based finite element analyses (2014)
  • Author(s): Miyuki Takasu, Yoko Kaichi, Chihiro Tani, Shuji Date, Masao Kiguchi, Kazuo Awai, Yoshiaki Kuroda and Akira Sakai
  • Organizer: RSNA2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] Magnetic Resonance Evaluation of Multiple Myeloma at 3.0 Tesla: How Do Bone Marrow Plasma Cell Percentage and (2014)
  • Author(s): Miyuki Takasu1, Yoko Kaichi1, Chihiro Tani1, Shuji Date1, Yuji Akiyama1, Yoshiaki Kuroda2, Akira Sakai3, and Kazuo Awai1
  • Organizer: ISMRM2014
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Interrelationships between 3T-MRI-, 64-section-MDCT-, and micro-CT-derived trabecular bone structure parameters: a study in cadavers (2014)
  • Author(s): Miyuki Takasu1, Chihiro Tani1, Daisuke Komoto1, Yoko Kaichi1, Shuji Date1, Yuji Akiyama1, Nobuhito Nango2, Masafumi Machida3, Kazuo Awai1
  • Organizer: ISMRM2014
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] CT-based finite element modeling and microstructural analysis detect reduced bone mineral content and bone strength in the spine after CT fluoroscopy-guided interventional procedures (2014)
  • Author(s): M. Takasu1, Y. Nakamura1, C. Tani1, Y. Kaichi1, D. Komoto1, S. Date1, T. Yamagami1, K. Awai1
  • Organizer: JRS2014
  • Place of Presentation: 横浜
  • Year and Date: 2014-04-10 – 2014-04-13