Basic and clinical study of dynamic color display ASL-MRA

• Project/Area Number: 26461800
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: Nishimura Shinichiro 熊本大学, 医学部附属病院, 非常勤診療医師 (50710448)
• Co-Investigator(Kenkyū-buntansha): 平井 俊範 宮崎大学, 医学部, 教授 (40274724)
• Research Collaborator: Iryo Yasuhiko 熊本大学, 医学部附属病院, 医員 ; Hiai Yasuhiro 熊本大学, 保健学科, 助教 ; Nakamura Masanobu メディカルサテライト八重洲クリニック
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: MRI / arterial spin labeling / 血管造影

Outline of Final Research Achievements

Temporal MR angiography (MRA) using arterial spin labeling (ASL) is a recently noted MRI technique, which allows a high time resolution like angiography without using a contrast agent. Among the techniques, the dynamic color display ASL-MRA is a state-of-the-art technology, but its basic performance and its clinical application have not yet been clarified. In this study, after optimizing the imaging condition of ASL-MRA, it was applied to healthy subjects, dura arteriovenous fistula, cerebral arteriovenous malformation, and cerebral artery occlusive disease and we clarified its usefulness.

Research Products

• [Journal Article] Evaluation of Intracranial Arteriovenous Malformations With Four-Dimensional Arterial-Spin Labeling-Based 3-T Magnetic Resonance Angiography (2016)
  • Author(s): Iryo Y, Hirai T, Nakamura M, Kawano T, Kaku Y, Ohmori Y, Kai Y, Azuma M, Nishimura S, Shigematsu Y, Kitajima M, Yamashita Y
  • Journal Title: J Comput Assist Tomogr Volume: 40 Issue: 2 Pages: 290-296
  • DOI: 10.1097/rct.0000000000000346
  • Peer Reviewed
• [Journal Article] Evaluation of Intracranial Vasculatures in Healthy Subjects with Arterial-Spin-Labeling-Based 4D-MR Angiography at 3T (2016)
  • Author(s): Iryo Y, Hirai T, Nakamura M, Tateishi M, Hayashida E, Azuma M, Nishimura S, Kitajima M, Yamashita Y.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 15 Issue: 3 Pages: 335-339
  • DOI: 10.2463/mrms.tn.2015-0081
  • NAID: 130005163445
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Collateral circulation via the circle of Willis in patients with carotid artery steno-occlusive disease: evaluation on 3-T 4D MRA using arterial spin labelling (2015)
  • Author(s): Iryo Y, Hirai T, Nakamura M, Inoue Y, Watanabe M, Ando Y, Azuma M, Nishimura S, Shigematsu Y, Kitajima M, Yamashita Y
  • Journal Title: Clinical Radiology Volume: 70 Issue: 9 Pages: 960-965
  • DOI: 10.1016/j.crad.2015.05.002
  • Peer Reviewed
• [Journal Article] Intracranial dural arteriovenous fistulas: evaluation with 3-T four-dimensional MR angiography using arterial spin labeling (2014)
  • Author(s): Iryo Y, Hirai T, Kai Y, Nakamura M, Shigematsu Y, Kitajima M, Azuma M, Komi M, Morita K, Yamashita Y
  • Journal Title: Radiology Volume: 271 Issue: 1 Pages: 193-199
  • DOI: 10.1148/radiol.13122670
  • Peer Reviewed