| Project/Area Number |
26461810
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
Kakeda Shingo 産業医科大学, 医学部, 講師 (30352313)
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| Co-Investigator(Kenkyū-buntansha) |
興梠 征典 産業医科大学, 医学部, 教授 (60195691)
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| Co-Investigator(Renkei-kenkyūsha) |
OKADA Kazumasa 産業医科大学, 医学部, 准教授 (30341499)
YONEDA Tetsuya 熊本大学, 医歯学系, 准教授 (20305022)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 多発性硬化症 / MRI / 位相差強調画像 / 定量的磁化率マッピング / 磁化率 / 皮質病変 / 位相 / 白質障害 |
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| Outline of Final Research Achievements |
We assessed 1) whether phase difference enhanced imaging (PADRE) is useful for the detection of gray matter involvement in the juxtacortical multiple sclerosis (MS) lesions and 2) whether the normal-appearing white matter (NAWM) regions surrounding MS lesions have abnormal quantitative susceptibility mapping (QSM) value. In results, the MR imaging with PADRE may increase the sensitivity in cortical lesion detection in the multiple sclerosis brain, as well as improved distinction between juxtacortical and mixed white matter-gray matter lesions. We also found that, in the patients with MS, the QSM values were abnormal in the normal-appearing white matter (NAWM) regions surrounding MS lesions. Our data suggest that the susceptibility imaging technique (PADRE and QSM) is useful for the evaluation of MS lesions.
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