Assessment of lesions in multiple sclerosis using phase difference-enhanced imaging (PADRE) and quantitative susceptibility mapping (QSM)
Project/Area Number |
26461810
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
Kakeda Shingo 産業医科大学, 医学部, 講師 (30352313)
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Co-Investigator(Kenkyū-buntansha) |
興梠 征典 産業医科大学, 医学部, 教授 (60195691)
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Co-Investigator(Renkei-kenkyūsha) |
OKADA Kazumasa 産業医科大学, 医学部, 准教授 (30341499)
YONEDA Tetsuya 熊本大学, 医歯学系, 准教授 (20305022)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 多発性硬化症 / MRI / 位相差強調画像 / 定量的磁化率マッピング / 磁化率 / 皮質病変 / 位相 / 白質障害 |
Outline of Final Research Achievements |
We assessed 1) whether phase difference enhanced imaging (PADRE) is useful for the detection of gray matter involvement in the juxtacortical multiple sclerosis (MS) lesions and 2) whether the normal-appearing white matter (NAWM) regions surrounding MS lesions have abnormal quantitative susceptibility mapping (QSM) value. In results, the MR imaging with PADRE may increase the sensitivity in cortical lesion detection in the multiple sclerosis brain, as well as improved distinction between juxtacortical and mixed white matter-gray matter lesions. We also found that, in the patients with MS, the QSM values were abnormal in the normal-appearing white matter (NAWM) regions surrounding MS lesions. Our data suggest that the susceptibility imaging technique (PADRE and QSM) is useful for the evaluation of MS lesions.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Juxtacortical Lesions in Multiple Sclerosis: Assessment of Gray Matter Involvement Using Phase Difference-enhanced Imaging (PADRE)2016
Author(s)
Futatsuya K, Kakeda S, Yoneda T, Ueda I, Watanabe K, Moriya J, Murakami Y, Ide S, Ogasawara A, Ohnari N, Okada K, Adachi H, Korogi Y.
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 15
Issue: 4
Pages: 349-354
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed
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[Journal Article] Improved Detection of Cortical Gray Matter Involvement in Multiple Sclerosis with Quantitative Susceptibility Mapping.2015
Author(s)
Kakeda S, Futatsuya K, Ide S, Watanabe K, Miyata M, Moriya J, Ogasawara A, Sato T, Narimatsu H, Okada K, Uozumi T, Liu T, Wang Y, Korogi Y.
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Journal Title
Acad Radiol.
Volume: 22
Issue: 11
Pages: 1427-32
DOI
Related Report
Peer Reviewed
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[Journal Article] RELATIONSHIP BETWEEN THE CORTICAL THICKNESS AND SERUM CORTISOL LEVELS IN DRUG-NAÏVE, FIRST-EPISODE PATIENTS WITH MAJOR DEPRESSIVE DISORDER: A SURFACE-BASED MORPHOMETRIC STUDY.2015
Author(s)
Liu X, Kakeda S, Watanabe K, Yoshimura R, Abe O, Ide S, Hayashi K, Katsuki A, Umeno-Nakano W, Watanabe R, Ueda I, Moriya J, Nakamura J, Korogi Y.
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Journal Title
Depress Anxiety.
Volume: 32
Issue: 9
Pages: 702-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: Voxel-based morphometry analysis.2015
Author(s)
Watanabe K, Kakeda S, Yoshimura R, Abe O, Ide S, Hayashi K, Katsuki A, Umene-Nakano W, Watanabe R, Nakamura J, Korogi Y.
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Journal Title
Psychiatry Res.
Volume: 30
Issue: 3
Pages: 481-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder: A VBM analysis of brain MRI2015
Author(s)
Ide S, Kakeda S, Watanabe K, Yoshimura R, Abe O, Hayashi K, Ueda I, Kishi T, Katsuki A, Umene-Nakano W, Iwata N, Nakamura J, Korogi Y.
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Journal Title
Psychiatry Res.
Volume: 30
Issue: 2
Pages: 120-4
DOI
Related Report
Peer Reviewed
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[Journal Article] Usefulness of quantitative susceptibility mapping for the diagnosis of Parkinson disease.2015
Author(s)
Murakami Y, Kakeda S, Watanabe K, Ueda I, Ogasawara A, Moriya J, Ide S, Futatsuya K, Sato T, Okada K, Uozumi T, Tsuji S, Liu T, Wang Y, Korogi Y.
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Journal Title
AJNR Am J Neuroradiol.
Volume: 36
Issue: 6
Pages: 1102-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Internal structures of the globus pallidus in patients with Parkinson's disease: evaluation with quantitative susceptibility mapping (QSM).2015
Author(s)
de S, Kakeda S, Ueda I, Watanabe K, Murakami Y, Moriya J, Ogasawara A, Futatsuya K, Sato T, Ohnari N, Okada K, Matsuyama A, Fujiwara H, Hisaoka M, Tsuji S, Liu T, Wang Y, Korogi Y.
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Journal Title
Eur Radiol
Volume: 25
Issue: 3
Pages: 710-8
DOI
Related Report
Peer Reviewed
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