Establishment of screening method for early hepatocellular carcinoma using novel MR transporter imaging using Gd-EOB-DTPA

• Project/Area Number: 26461819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: KOBAYASHI Satoshi 金沢大学, 保健学系, 教授 (30313638)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肝細胞癌 / 磁気共鳴画像 / Gd-EOB-DTPA / MRI / 肝臓 / 肝硬変 / 肝腫瘍 / トランスポーター

Outline of Final Research Achievements

Hepatobiliary phase of Gd-EOB-DTPA (EOB) enhanced MRI which is used for detection of early hepatocellular carcinoma, occasionally shows poor image quality. In this analysis, if the case shows Child A or B liver damage, poor quality image obtained on hepatobiliary phase (HBP) is improved on super-delayed phase (SDP) image acquisition which is about 60 minutes after HBP. However, if the case shows Child C liver damage, improvement of image quality on SDP is not expected.

Research Products

• [Journal Article] Hepatobiliary phase images using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI as an imaging surrogate for the albumin-bilirubin grading system. (2016)
  • Author(s): Takatsu Y, Kobayashi S, Miyati T, Shiozaki T.
  • Journal Title: Eur J Radiol Volume: 85 Pages: 2206-2210
  • DOI: 10.1016/j.ejrad.2016.10.010
  • Peer Reviewed
• [Journal Article] A novel method for evaluating enhancement using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid in the hepatobiliary phase of magnetic resonance imaging. (2016)
  • Author(s): Takatsu Y, Kobayashi S, Miyati T, Shiozaki T.
  • Journal Title: Clin Imaging. Volume: 40 Pages: 1112-1117
  • DOI: 10.1016/j.clinimag.2016.07.001
• [Journal Article] Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome. (2015)
  • Author(s): Yoneda N, Matsui O, Ikeno H, Inoue D, Yoshida K, Kitao A, Kozaka K, Kobayashi S, Gabata T, Ikeda H, Nakamura K, Ohta T.
  • Journal Title: Abdom Imaging Volume: 40 Pages: 3099-3103
  • DOI: 10.1007/s00261-015-0503-z
  • Peer Reviewed / Open Access
• [Journal Article] Hepatocellular Carcinoma with β-Catenin Mutation: Imaging and Pathologic Characteristics. (2015)
  • Author(s): Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Sanada J, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Nakanuma Y, Kita R, Gabata T.
  • Journal Title: Radiology Volume: 275 Pages: 708-17
  • DOI: 10.1148/radiol.14141315
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The significance and indication of super-delayed phase image acquisition of Gd-EOB-DTPA enhanced MRI to improve poor contrast images on routine hepatobiliary phase images for detection of liver lesion. (2016)
  • Author(s): S. Kobayashi, K. Kozaka, T. Minami, A. Kitao, Y. Yoshida, N. Yoneda, H. W. Koda, T. Gabata.
  • Organizer: 33th Annual Scientific Meeting of European Society for Magnetic Resonance in Medicine and Biology
  • Place of Presentation: Vienna (Austria)
  • Year and Date: 2016-09-30
  • Int'l Joint Research
• [Presentation] Technical Aspects of Optimization for Gadoxetic Acid-enhanced Liver MR Imaging. (2014)
  • Author(s): Satoshi Kobayashi , Naoki Ohno, Yasunari Fujinaga, Tosiaki Miyati, Toshifumi Gabata, Osamu Matsui, Hiroshi Ikeno, Wataru Koda, Kazuto Kozaka, Dai Inoue, Kotaro Yoshida, Norihide Yoneda, Tetsuya Minami.
  • Organizer: RSNA 2014 100th Scientific assembly and annual meeting
  • Place of Presentation: McCormick Place (米国 シカゴ)
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] Indication of super-delayed phase image acquisition of Gd-EOB-DTPA enhanced MRI to improve poor contrast images on routine hepatobiliary phase images for detection of liver lesion (2014)
  • Author(s): Kobayashi S, Kozaka K, Kitao A, Yoneda N, Ikeno H, Matsui O, Gabata T.
  • Organizer: AASLD
  • Place of Presentation: Hynes Convention Center (米国 ボストン)
  • Year and Date: 2014-11-07 – 2014-11-11