Bone and cartilage lesions of the wrist in rheumatoid arthritis: Evaluation by 3-Tesla high-resolution MR imaging

• Project/Area Number: 26461829
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagasaki University
• Principal Investigator: UETANI Masataka 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40176582)
• Co-Investigator(Kenkyū-buntansha): 川尻 真也 長崎大学, 医歯薬学総合研究科(医学系), 講師 (20457576) ; 川上 純 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90325639)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 関節リウマチ / MRI / CT / 手関節 / 骨髄浮腫 / 骨びらん / 関節軟骨 / 軟骨下骨

Outline of Final Research Achievements

The purpose of this study is to clarify the utility of 3 Tesla high-resolution MR imaging of the wrist for demonstration of bone erosions and bone marrow edema (BME) in cases of rheumatoid arthritis (RA). High-resolution MR images precisely showed erosions in over 90% of joints, which were confirmed by high-resolution CT images. In follow-up MR studies, joints with BME showed progression to bone erosions more frequently than those without BME. The results provide an additional evidence that BME is a forerunner of bone erosion and progression in RA.

Research Products

• [Journal Article] Baseline MRI bone erosion predicts the subsequent radiographic progression in early rheumatoid arthritis patients who achieved sustained good clinical response. (2017)
  • Author(s): Tamai M, Arima K, Nakashima Y, Kita J, Umeda M, Fukui S, Nishino A, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri SY, Iwamoto N, Ichinose K, Yamasaki S, Nakamura H, Origuchi T, Aoyagi K, Uetani M, Eguchi K, Kawakami A
  • Journal Title: Mod Rheumatol Volume: 印刷中 Issue: 6 Pages: 1-6
  • DOI: 10.1080/14397595.2017.1294280
  • Peer Reviewed
• [Journal Article] MRI bone oedema at enrollment predicts rapid radiographic progression over 1 year in early rheumatoid arthritis patients: results from the Nagasaki University Early Arthritis Cohort (2016)
  • Author(s): Nakashima Y, Tamai M, Kita J, Michitsuji T, Shimizu T, Fukui S, Umeda M, Nishino A, Suzuki S, Yoshiro Horai, Akitomo Okada, Takayuki Nishimura, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Yasuko Hirai, Arima K, Yamasaki S, Nakamura H, Origuchi T, Takao S, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Journal Title: Journal of Rheumatology Volume: 43 Issue: 7 Pages: 7-13
  • DOI: 10.3899/jrheum.150988
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Magnetic Resonance Imaging Bone Edema at Enrollment Predicts Rapid Radiographic Progression in Patients with Early RA: Results from the Nagasaki University Early Arthritis Cohort. (2016)
  • Author(s): Nakashima Y, Tamai M, Kita J, Michitsuji T, Shimizu T, Fukui S, Umeda M, Nishino A, Suzuki T, Horai Y, Okada A, Nishimura T, Koga T, Kawashiri SY, Iwamoto N, Ichinose K, Hirai Y, Arima K, Yamasaki S, Nakamura H, Origuchi T, Takao S, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Journal Title: J Rheumatol Volume: 印刷中
• [Journal Article] Automated Breast Volume Scanner, a new automated ultrasonic device, is useful to examine joint injuries in patients with rheumatoid arthritis. (2015)
  • Author(s): Kawashiri SY, Suzuki T, Nishino A, Nakashima Y, Horai Y, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Isomoto I, Uetani M, Aoyagi K, Kawakami A
  • Journal Title: Mod Rheumatol Volume: 25 Issue: 6 Pages: 837-841
  • DOI: 10.3109/14397595.2015.1040226
  • Peer Reviewed
• [Journal Article] 医学と医療の最前線 関節炎の画像評価の進歩と課題 (2015)
  • Author(s): 川上 純, 川尻 真也, 玉井 慎美, 上谷 雅孝
  • Journal Title: 日本内科学会雑誌 Volume: 104 Pages: 788-795
• [Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis. (2014)
  • Author(s): Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Nishino A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
  • Journal Title: Rheumatology (Oxford). Volume: - Issue: 8 Pages: 1452-1456
  • DOI: 10.1093/rheumatology/keu034
  • Peer Reviewed
• [Journal Article] Combination of MRI-detcted bone marrow oedema with 2010 rheumatoid arthritis classification criteria improves the diagnostic probability early rheumatoid arthritis. (2014)
  • Author(s): Tamai M, Kita J, Nakashima Y, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Yama-saki S, Nakamura H, Origuchi T, Uetani M,Fukushima A, Aoyagi K, Kawakami A.
  • Journal Title: Annals of Rheumatic Diseases Volume: 73 Issue: 12 Pages: 2219-20
  • DOI: 10.1136/annrheumdis-2013-205074
  • Peer Reviewed / Open Access
• [Journal Article] Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion. (2014)
  • Author(s): Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Tamai M, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
  • Journal Title: Rheumatology (Oxford). Volume: 53 Issue: 3 Pages: 562-569
  • DOI: 10.1093/rheumatology/ket405
  • NAID: 120006986675
  • Peer Reviewed
• [Journal Article] 【最新関節リウマチ学-寛解・治癒を目指した研究と最新治療-】 関節リウマチの検査・診断 検査 画像検査 関節MRI、超音波検査 (2014)
  • Author(s): 玉井 慎美, 上谷 雅孝, 川尻 真也, 川上 純
  • Journal Title: 日本臨床 Volume: 72 Pages: 253-257
• [Presentation] 関節リウマチの関節裂隙狭小化のMRIによる評価 (2016)
  • Author(s): 玉井慎美, 上谷雅孝, 岩本直樹, 古賀智裕, 青柳 潔, 川上 純
  • Organizer: 第44回日本臨床免疫学会
  • Place of Presentation: 京王プラザホテル（東京都、新宿区）
• [Presentation] 脊椎関節炎の診断における仙腸関節と脊椎のMRI (2016)
  • Author(s): 上谷雅孝
  • Organizer: 日本脊椎関節炎学会第26回学術集会
  • Place of Presentation: 京王プラザホテル（東京都、新宿区）
  • Invited
• [Presentation] MRI Bone Erosion at Baseline Predicts the Subsequent Radiographic Progression in Early-Stage RA Patients Who Achieved in Sustained Clinical Good Response: Sub-Analysis from Nagasaki University Early Arthritis Cohort. (2015)
  • Author(s): Tamai M, Nakashima Y, Arima K, Kita J, Umeda M, Fukui S, Nishino A, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Yamasaki S, Nakamura H, Origuchi T, Aoyagi K, Uetani M, Eguchi K, Kawakami A
  • Organizer: 2015 ACR/AHRP Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] 早期関節リウマチにおけるMRIスコアとX線スコアの検討 (2015)
  • Author(s): 玉井 慎美, 中島 好一, 上谷 雅孝, 川上 純
  • Organizer: 日本臨床免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫県・神戸市）
  • Year and Date: 2015-10-22
• [Presentation] MRI-proven Bone Marrow Oedema at Baseline Is the Strongest Predictor Toward the Development of Rapid Radiographic Progression at 1 Year in Patients with Early-Stage Rheumatoid Arthritis: Results from Nagasaki University Early Arthritis Cohort. (2015)
  • Author(s): Nakashima Y, Tamai M, Kita J, Tuji S, Fukui S, Umeda M, Fukui S, Nishino A, Suzuki T, Horai Y, Nishimura T, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Hirai Y, Arima K, Yamasaki S, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Organizer: EULAR Congress 2015
  • Place of Presentation: Rome, USA
  • Year and Date: 2015-06-10
  • Int'l Joint Research
• [Presentation] MRI Bone Erosion at Baseline Predicts the Subsequent Radiographic Progression in Early-Stage RA Patients Who Achieved in Sustained Clinical Good Response: Sub-Analysis from Nagasaki University Early Arthritis Cohort. (2015)
  • Author(s): Tamai M, Arima K, NakashimaY, Kita J, Umeda M, Fukui S, Nishino A, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Yamasaki S, Nakamura H, Origuchi T, Aoyagi K, Uetani M, Eguchi K, Kawakami A
  • Organizer: EULAR Congress 2015
  • Place of Presentation: Rome, Italy
  • Year and Date: 2015-06-10
  • Int'l Joint Research
• [Presentation] 長崎早期関節コホートを用いて解析するMRI骨炎の意義 (2015)
  • Author(s): 中島 好一, 玉井 慎美, 喜多 潤子, 福井 翔一, 梅田 雅孝, 西野 文子, 鈴木 貴久, 寶來 吉朗, 岡田 覚丈, 古賀 智裕, 川尻 真也, 岩本 直樹, 一瀬 邦弘, 平井 康子, 有馬 和彦, 中村 英樹, 折口 智樹, 上谷 雅孝, 青柳 潔, 江口 勝美, 川上 純
  • Organizer: 日本リウマチ学会総会・学術集会・国際リウマチシンポジウム
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-04-23
• [Presentation] Search under the Cartilage: A Gamut of Subchondral Lesions (2014)
  • Author(s): Farhana S, Uetani M, Mursalin R, Yamaguchi T
  • Organizer: Radiological Society of North America 2014
  • Place of Presentation: McCormick Place (Chicago)
  • Year and Date: 2014-11-29 – 2014-12-05
• [Presentation] Investigation of MRI Bone Changes in Early-Stage RA Patients Achieved in Sustained Clinical Good Response: Sub-Analysis from Nagasaki University Early Arthritis Cohort. (2014)
  • Author(s): Tamai M, Arima K, Nakashima Y, Umeda M, Fukui S, Nishino A, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Nakamura H, Origuchi T, Uetani M, Aoyagi K , Kawakami A
  • Organizer: 2014 ACR/ARHP Annual Meeting
  • Place of Presentation: Boston Convention & Exhibition Center (Boston)
  • Year and Date: 2014-11-14 – 2014-11-19
• [Presentation] MRI Osteitis at Baseline Predicts the Development of Rapid Radiographic Progression at 1 Year Toward Patients with Early-Stage Rheumatoid Arthritis. (2014)
  • Author(s): Nakashima Y, Tamai M, Kita J, Tsuji S, Fukui S, Umeda M, Nishino A, Suzuki T, Horai Y, AOkada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Hirai Y, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Organizer: 2014 ACR/ARHP Annual Meeting
  • Place of Presentation: Boston Convention & Exhibition Center (Boston)
  • Year and Date: 2014-11-14 – 2014-11-19
• [Presentation] 関節リウマチにおける治療によるMRI骨炎の推移とX線進行 (2014)
  • Author(s): 玉井 慎美, 中島 好一, 上谷 雅孝, 梅田 雅孝, 福井 翔一, 西野 文子, 鈴木 貴久, 寶来 吉朗, 川尻 真也, 古賀 智裕, 岩本 直樹, 一瀬 邦弘, 有馬 和彦, 中村 英樹, 折口 智樹, 青柳 潔, 川上 純
  • Organizer: 第42回日本臨床免疫学会
  • Place of Presentation: 京王プラザホテル (東京)
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Ultrasound Disease Activity at 3 Months Predicts the Clinical Response at 6 Months of Patients with Rheumatoid Arthritis Treated by Biologic Disease Modifying Anti-Rheumatic Drugs (2014)
  • Author(s): Kawashiri S, Nishino A, Suzuki T. Nakashima Y, Horai Y, Iwamoto N,. Ichinose K, Arima K, Tamai M, Nakamura H , Origuchi T , Uetani M , Aoyagi K , Eguchi K, Kawakami A
  • Organizer: EULAR 2014
  • Place of Presentation: Le Palais des Congres de Paris - Palais des Congres (Paris)
  • Year and Date: 2014-07-11 – 2014-07-14
• [Presentation] 画像診断の進歩： MRIを用いた関節リウマチの画像評価 (2014)
  • Author(s): 上谷雅孝
  • Organizer: 第58回日本リウマチ学会総会・学術集会・国際リウマチシンポジウム
  • Place of Presentation: グランドプリンスホテル新高輪 (東京)
  • Year and Date: 2014-04-24 – 2014-04-26
  • Invited
• [Presentation] 画像診断の進歩：超音波を用いた関節リウマチの診断と治療の評価 MRIとの比較を含めて (2014)
  • Author(s): 川尻 真也,, 玉井 慎美, 上谷 雅孝, 青柳 潔, 川上 純
  • Organizer: 第58回日本リウマチ学会総会・学術集会・国際リウマチシンポジウム
  • Place of Presentation: グランドプリンスホテル新高輪 (東京)
  • Year and Date: 2014-04-24 – 2014-04-26
  • Invited
• [Presentation] 強化治療による早期関節リウマチの臨床的疾患活動性とX線予後の改善 (2014)
  • Author(s): 玉井 慎美, 中島 好一, 喜多 潤子, 有馬 和彦, 川尻 真也, 中村 英樹, 上谷 雅孝, 青柳 潔, 江口 勝美, 川上 純
  • Organizer: 第111回日本内科学会
  • Place of Presentation: 東京国際フォーラム (東京)
  • Year and Date: 2014-04-11 – 2014-04-13
• [Book] 臓器別画像解析の基礎知識 (2015)
  • Author(s): 上谷雅孝
  • Total Pages: 279
  • Publisher: 医薬ジャーナル社
• [Book] 骨軟部画像診断スタンダード (2014)
  • Author(s): 上谷雅孝
  • Total Pages: 386
  • Publisher: メディカルサイエンスインターナショナル