Development of imaging technique to preclinically diagnose Alzheimer's disease using clnical MRI

• Project/Area Number: 26461830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: Tetsuya Yoneda 熊本大学, 大学院生命科学研究部(保), 准教授 (20305022)
• Co-Investigator(Kenkyū-buntansha): 平井 俊範 宮崎大学, 医学部, 教授 (40274724) ; 橋本 衛 熊本大学, 大学院生命科学研究部(医), 准教授 (20452881) ; 池田 学 大阪大学, 医学系研究科, 教授 (60284395)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: MRI / 認知症 / 位相画像 / アミロイド / アルツハイマー病 / 位相 / AD / アミロイドβ / アミロイド老人斑 / アミロイド斑

Outline of Final Research Achievements

The aim of this study was to develop imaging technique to quantitatively detect amyloid plaque as a cause of Alzheimer's disease and preclinically diagnose Alzheimer's disease by using clinical MRI. This study used phase information of MRI for detecting amyloid plaque so as to quantitatively detect it on any clinical MRI. We concluded that phase information might quantitatively detect amyloid plaque with 3D multi-echo GRE sequence and subtraction between phase signal of super frontal gyrus and one of the other gyrus might be correlated with MMES score.

Research Products

• [Int'l Joint Research] Siriraj病院(タイ)
• [Int'l Joint Research] NeuRA(オーストラリア)
• [Int'l Joint Research] Leiden Univeristy Medical Center/Philips Healthcare(オランダ)
• [Int'l Joint Research] Siriraj病院(タイ)
• [Int'l Joint Research] NeuRa/New South Weals University/St. Vincent Hospital(オーストラリア)
• [Int'l Joint Research] Leiden University(オランダ)
• [Int'l Joint Research] Philips Healthcare(オランダ)
• [Int'l Joint Research] Philips Healthcare/Leiden University(オランダ)
• [Int'l Joint Research] ソウル大学(韓国)
• [Int'l Joint Research] Siriraj Hospital/Ramathibodi Hospital(タイ)
• [Int'l Joint Research] Neuroscience Research Australia/New South Wales University/St Vincent's Hospital(オーストラリア)
• [Journal Article] Characteristic phase distribution in the white matter of infants on phase difference enhanced imaging (2019)
  • Author(s): Tesu Niwa Tetsuya Yoneda Masaharu Hayashi Keiji Suzuki Shuhei Shibukawa Takashi Okazaki Yutaka Imai
  • Journal Title: Journal of Neuroradiology Volume: 印刷中 Issue: 6 Pages: 374-379
  • DOI: 10.1016/j.neurad.2018.03.001
  • Peer Reviewed / Open Access
• [Journal Article] Differentiating between Alzheimer Disease Patients and Controls with Phase-difference-enhanced Imaging at 3T: A Feasibility Study (2018)
  • Author(s): Tateishi Machiko、Kitajima Mika、Hirai Toshinori、Yoneda Tetsuya、Hashimoto Mamoru、Kurehana Nan、Uetani Hiroyuki、Fukuhara Ryuji、Azuma Minako、Yamashita Yasuyuki
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 17 Issue: 4 Pages: 283-292
  • DOI: 10.2463/mrms.mp.2017-0134
  • NAID: 130007496648
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Signal Change of Acute Cortical and Juxtacortical Microinfarction on Follow-Up MRI (2018)
  • Author(s): Miyata, M. Kakeda, S. Yoneda, T. Ide, S. Watanabe, K. Moriya, J. Korogi, Y.
  • Journal Title: AJNR Am J Neuroradiol Volume: 印刷中 Issue: 5 Pages: 834-840
  • DOI: 10.3174/ajnr.a5606
  • Peer Reviewed / Open Access
• [Journal Article] Internal Structures of the Globus Pallidus in Patients with Parkinson’s Disease: Evaluation with Phase Difference-enhanced Imaging (2017)
  • Author(s): Satoru Ide, Shingo Kakeda, Tetsuya Yoneda, Junji Moriya, Keita Watanabe, Atsushi Ogasawara, Koichiro Futatsuya, Norihiro Ohnari, Toru Sato, Yasuhiro Hiai, Atsuji Matsuyama, Hitoshi Fujiwara, Masanori Hisaoka, Yukunori Korogi
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: -
  • NAID: 130006163824
  • Peer Reviewed / Open Access
• [Journal Article] Juxtacortical Lesions in Multiple Sclerosis: Assessment of Gray Matter Involvement Using Phase Difference-enhanced Imaging (PADRE) (2016)
  • Author(s): Koichiro FUTATSUYA, Shingo KAKEDA, Tetsuya YONEDA, Issei UEDA, Keita WATANABE, Junji MORIYA, Yu MURAKAMI, Satoru IDE, Atsushi OGASAWARA, Norihiro OHNARI, Kazumasa OKADA, Hiroaki ADACHI, Yukunori KOROGI
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 15 Pages: 349-354
  • NAID: 130005421021
  • Peer Reviewed / Open Access
• [Journal Article] Zebra sign of precentral gyri in amyotrophic lateral sclerosis: A novel finding using phase difference enhanced (PADRE) imaging-initial results (2016)
  • Author(s): Shingo Kakeda, Tetsuya Yoneda, Satoru Ide, Mari Miyata, Tomoyo Hashimoto, Koichiro Futatsuya, Keita Watanabe, Atsushi Ogasawara, Junji Moriya, Toru Sato, Kazumasa Okada, Takenori Uozumi, Hiroaki Adachi, Yukunori Korogi
  • Journal Title: European Radiology Volume: 26 Issue: 11 Pages: 4173-4183
  • DOI: 10.1007/s00330-016-4219-4
  • Peer Reviewed / Open Access
• [Journal Article] Lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with Parkinson disease measured with quantitative susceptibility mapping (2016)
  • Author(s): Azuma M, Hirai T, Yamada K, Yamashita S, Ando Y, Tateishi M, Iryo Y, Yoneda T, Kitasima M, Wang Y, Yamashita Y
  • Journal Title: Am. J. Neuroradiol Volume: 0 Issue: 5 Pages: 1-7
  • DOI: 10.3174/ajnr.a4645
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping (2016)
  • Author(s): Azuma M, Hirai T, Yamada K, Yamashita S, Ando Y, Tateishi M, Iryo Y, Yoneda T, Kitajima M, Wang Y, Yamashita Y
  • Journal Title: American Journal of Neuroradiology
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Signal intensity of superficial white matter on phase difference enhanced imaging as a landmark of the perirolandic cortex (2016)
  • Author(s): Kakeda S, Yoneda T, Ide S, Watanabe K, Hiai Y, Korogi Y
  • Journal Title: Academic Radiology
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Zebra sign of precentral gyri in amyotrophic lateral sclerosis: A novel finding using phase difference enhanced (PADRE) imaging-initial results (2016)
  • Author(s): Kakeda S, Yoneda T, Ide S, Miyata M, Hashimoto T, Futatsuya K, Watanabe K, Ogasawara A, Moriya J, Sato T, Okada K, Uozumi T, Adachi H, Korogi Y
  • Journal Title: European Radiology
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Juxtacortical Lesions in Multiple Sclerosis: Assessment of Gray Matter Involvement Using Phase Difference-enhanced Imaging (PADRE) (2016)
  • Author(s): Futatsuya K, Kakeda S, Yoneda T, Ueda I, Watanabe K, Moriya J, Murakami Y, Ide S, Ogasawara A, Ohnari N, Okada K, Adachi H, Korogi Y
  • Journal Title: Magnetic Resonace in Medical Sciences
  • NAID: 130005421021
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Visualization of the Medial and Lateral Geniculate Nucleus on Phase Difference Enhanced Imaging (2015)
  • Author(s): Kitajima M, Hirai T, Yoneda T, et al.
  • Journal Title: American Journal of Neuroradiology Volume: 36 Issue: 9 Pages: 1669-1674
  • DOI: 10.3174/ajnr.a4356
  • Peer Reviewed
• [Journal Article] Visualization of the Medial and Lateral Geniculate Nucleus on Phase Difference Enhanced Imaging (2015)
  • Author(s): Mika Kitajima, Toshinori Hirai, Tetsuya Yoneda, Yasuhiko Iryou, Minako Azuma, Yoshinori Shigematsu, Masanori Komi, Kosuke Morita, Machiko Tateishi, Yasuyuki Yamashita
  • Journal Title: American Journal of Neuroradiology
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] ROI-based phase analysis for neuronal current MRI (2018)
  • Author(s): T. Yoneda, M. Iwata, H. Indo, N. Kurehana, S. Yoshinaga, M. Takeda, H. Terasawa
  • Organizer: European Congress of Radiology 2018
  • Int'l Joint Research
• [Presentation] Study on MR-Phase Distribution of Iron to Detect Amyloid-beta Plaque (2017)
  • Author(s): Tetsuya Yoneda, Nan Kurehana, Hiroki Indo, Saki Tajima, Saki Nozoe, Miki Sawano, Koji Hashimoto and Akihiko Kuniyasu
  • Organizer: Australian and New Zealand Society of Magnetic Resonance Conference 2017
  • Int'l Joint Research / Invited
• [Presentation] Phase Information Enables Amyloid Plaque Imaging of the Human Brain on Clinical MRI (2015)
  • Author(s): N Kurehana, T. Yoneda, K. Hashimoto, M. Tateishi, M. Azuma, M. Kitajima, M. Hashimoto, S. Yoshinaga, A. Kuniyasu, H. Terasawa, T. Hirai, M. Ikeda, Y. Yamashita
  • Organizer: RSNA 2015
  • Place of Presentation: McCormick Place（シカゴ）
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Alzheimer's disease: diagnostic potential of phase difference enhanced MR imaging at 3T (2015)
  • Author(s): M. Tateishi, M. Kitajima, T. Hirai, T. Yoneda, M. Azuma, M. Ikeda, M. Hashimoto, Y. Yamashita
  • Organizer: RSNA 2015
  • Place of Presentation: McCormick Place（シカゴ）
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Phase Difference Enhanced Imaging (PADRE) as a Novel Phase Imaging Tool for CNS (2015)
  • Author(s): Tetsuya Yoneda
  • Organizer: AOCNR 2015
  • Place of Presentation: Hilton Fukuoka Sea Hawk（福岡）
  • Year and Date: 2015-11-05
  • Int'l Joint Research / Invited
• [Presentation] Phase Information as a Non-invasive Tool with High Detectability of Amyloid Plaque (2015)
  • Author(s): Nan Kurehana, Tetsuya Yoneda, Koji Hashimoto, Machiko Tateishi, Ryuji Fukuhara, Mika Kitajima, Mamoru Hashimoto, Akihiko Kuniyasu, Toshinori Hirai, Manabu Ikeda, Yasuyuki Yamashita
  • Organizer: The 9th International Congress of the Asian Society Against Dementia
  • Place of Presentation: KKRホテル（熊本）
  • Year and Date: 2015-09-14
  • Int'l Joint Research
• [Presentation] Phase Difference Enhanced Imaging (PADRE) as Novel Non-invasive Tool for Amyloid Plaque Detection (2015)
  • Author(s): Yoneda Tetsuya, Kurehana Nan, Hashimoto Koji, Tateishi Machiko, Fukuhara Ryuji, Kitajima Mika, Hashimoto Mamoru, Kuniyasu Akihiko, Hirai Toshinori, Ikeda Manabu, Yamashita Yasuyuki
  • Organizer: The 9th International Congress of the Asian Society Against Dementia
  • Place of Presentation: KKRホテル（熊本）
  • Year and Date: 2015-09-14
  • Int'l Joint Research
• [Presentation] 位相画像情報を用いたアミロイドプラーク検出技術の定量・定性的評価 (2015)
  • Author(s): 呉花楠、米田哲也、橋本弘司、立石真知子、東美菜子、北島美香、橋本衛、吉永壮佐、石井絢子、田崎有紀乃、國安明彦、寺沢弘明、平井俊範、池田学、山下康行
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル（東京都）
  • Year and Date: 2015-09-10
• [Presentation] アルツハイマー病における大脳皮質の位相差強調画像による評価 -第2報- (2015)
  • Author(s): 立石真知子、北島美香、平井俊範、東美菜子、井料保彦、橋本衛、呉花楠、米田哲也、池田学、山下康行
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル（東京都）
  • Year and Date: 2015-09-10
• [Presentation] 位相差強調画像化法PADREで診る (2015)
  • Author(s): 米田哲也
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル（東京都）
  • Year and Date: 2015-09-09
  • Invited
• [Presentation] 磁化率のMRI: SWIからQSMまで (2015)
  • Author(s): 米田哲也
  • Organizer: Advanced CT・MR 2015
  • Place of Presentation: 軽井沢プリンスホテル ウエスト（軽井沢）
  • Year and Date: 2015-06-06
  • Invited
• [Presentation] Parenchymal CNS hemorrhage: What the Physicist Can Add (2015)
  • Author(s): Tetsuya Yoneda
  • Organizer: ISMRM 2015
  • Place of Presentation: Metro Toronto Convention Centere（トロント）
  • Year and Date: 2015-05-30
  • Int'l Joint Research / Invited
• [Presentation] Statistical Phase Noise Elimination for Amyloid Plaque Detection (2015)
  • Author(s): Tetsuya Yoneda, Koji Hashimoto, Akihiko Kuniyasu, Toshinori Hirai, Mika Kitajima, Mamoru Hashimoto, Nan Kurehana, Michiya Iwata, Motohira Mio, Sosuke Yoshinaga, Hiroaki Terasawa, Manabu Ikeda, Yasuyuki Yamashita
  • Organizer: ISMRM 2015
  • Place of Presentation: Metro Toronto Convention Centere（トロント）
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Stripe sign of precentral gyri in amyotrophic lateral sclerosis: a novel Finding on PADRE (2014)
  • Author(s): 掛田伸吾、米田哲也、宮田真理、井手智、渡邉啓太、村上優、小笠原篤、森谷淳二、二ッ矢浩一郎、興梠征典
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: グランビア京都（京都市）
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] Identification of Heschl's gyrus on phase difference enhanced imaging (2014)
  • Author(s): 井手智、掛田伸吾、米田哲也、渡邉啓太、二ッ矢浩一郎、村上優、小笠原篤、森谷淳二、大成宜弘、興梠征典
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: グランビア京都（京都市）
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] アルツハイマー病における大脳皮質の位相差強調画像による評価 (2014)
  • Author(s): 東美菜子、平井俊範、井料保彦、立石真知子、北島美香、山下康行、橋本衛、池田学、米田哲也
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: グランビア京都（京都市）
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 位相差強調画像による新生児白質構造の描出 (2014)
  • Author(s): 丹羽徹、米田哲也、林雅晴、柳町徳春、風間俊基、渋川周平、中村智哉、鈴木啓二、高原太郎、今井裕
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: グランビア京都（京都市）
  • Year and Date: 2014-09-18 – 2014-09-20