Development of imaging technique to preclinically diagnose Alzheimer's disease using clnical MRI
Project/Area Number |
26461830
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Kumamoto University |
Principal Investigator |
Tetsuya Yoneda 熊本大学, 大学院生命科学研究部(保), 准教授 (20305022)
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Co-Investigator(Kenkyū-buntansha) |
平井 俊範 宮崎大学, 医学部, 教授 (40274724)
橋本 衛 熊本大学, 大学院生命科学研究部(医), 准教授 (20452881)
池田 学 大阪大学, 医学系研究科, 教授 (60284395)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | MRI / 認知症 / 位相画像 / アミロイド / アルツハイマー病 / 位相 / AD / アミロイドβ / アミロイド老人斑 / アミロイド斑 |
Outline of Final Research Achievements |
The aim of this study was to develop imaging technique to quantitatively detect amyloid plaque as a cause of Alzheimer's disease and preclinically diagnose Alzheimer's disease by using clinical MRI. This study used phase information of MRI for detecting amyloid plaque so as to quantitatively detect it on any clinical MRI. We concluded that phase information might quantitatively detect amyloid plaque with 3D multi-echo GRE sequence and subtraction between phase signal of super frontal gyrus and one of the other gyrus might be correlated with MMES score.
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Report
(5 results)
Research Products
(41 results)
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[Journal Article] Internal Structures of the Globus Pallidus in Patients with Parkinson’s Disease: Evaluation with Phase Difference-enhanced Imaging2017
Author(s)
Satoru Ide, Shingo Kakeda, Tetsuya Yoneda, Junji Moriya, Keita Watanabe, Atsushi Ogasawara, Koichiro Futatsuya, Norihiro Ohnari, Toru Sato, Yasuhiro Hiai, Atsuji Matsuyama, Hitoshi Fujiwara, Masanori Hisaoka, Yukunori Korogi
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: -
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Juxtacortical Lesions in Multiple Sclerosis: Assessment of Gray Matter Involvement Using Phase Difference-enhanced Imaging (PADRE)2016
Author(s)
Koichiro FUTATSUYA, Shingo KAKEDA, Tetsuya YONEDA, Issei UEDA, Keita WATANABE, Junji MORIYA, Yu MURAKAMI, Satoru IDE, Atsushi OGASAWARA, Norihiro OHNARI, Kazumasa OKADA, Hiroaki ADACHI, Yukunori KOROGI
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 15
Pages: 349-354
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Zebra sign of precentral gyri in amyotrophic lateral sclerosis: A novel finding using phase difference enhanced (PADRE) imaging-initial results2016
Author(s)
Shingo Kakeda, Tetsuya Yoneda, Satoru Ide, Mari Miyata, Tomoyo Hashimoto, Koichiro Futatsuya, Keita Watanabe, Atsushi Ogasawara, Junji Moriya, Toru Sato, Kazumasa Okada, Takenori Uozumi, Hiroaki Adachi, Yukunori Korogi
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Journal Title
European Radiology
Volume: 26
Issue: 11
Pages: 4173-4183
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with Parkinson disease measured with quantitative susceptibility mapping2016
Author(s)
Azuma M, Hirai T, Yamada K, Yamashita S, Ando Y, Tateishi M, Iryo Y, Yoneda T, Kitasima M, Wang Y, Yamashita Y
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Journal Title
Am. J. Neuroradiol
Volume: 0
Issue: 5
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping2016
Author(s)
Azuma M, Hirai T, Yamada K, Yamashita S, Ando Y, Tateishi M, Iryo Y, Yoneda T, Kitajima M, Wang Y, Yamashita Y
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Journal Title
American Journal of Neuroradiology
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Zebra sign of precentral gyri in amyotrophic lateral sclerosis: A novel finding using phase difference enhanced (PADRE) imaging-initial results2016
Author(s)
Kakeda S, Yoneda T, Ide S, Miyata M, Hashimoto T, Futatsuya K, Watanabe K, Ogasawara A, Moriya J, Sato T, Okada K, Uozumi T, Adachi H, Korogi Y
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Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Juxtacortical Lesions in Multiple Sclerosis: Assessment of Gray Matter Involvement Using Phase Difference-enhanced Imaging (PADRE)2016
Author(s)
Futatsuya K, Kakeda S, Yoneda T, Ueda I, Watanabe K, Moriya J, Murakami Y, Ide S, Ogasawara A, Ohnari N, Okada K, Adachi H, Korogi Y
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Journal Title
Magnetic Resonace in Medical Sciences
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Phase Information Enables Amyloid Plaque Imaging of the Human Brain on Clinical MRI2015
Author(s)
N Kurehana, T. Yoneda, K. Hashimoto, M. Tateishi, M. Azuma, M. Kitajima, M. Hashimoto, S. Yoshinaga, A. Kuniyasu, H. Terasawa, T. Hirai, M. Ikeda, Y. Yamashita
Organizer
RSNA 2015
Place of Presentation
McCormick Place(シカゴ)
Year and Date
2015-11-29
Related Report
Int'l Joint Research
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[Presentation] Phase Information as a Non-invasive Tool with High Detectability of Amyloid Plaque2015
Author(s)
Nan Kurehana, Tetsuya Yoneda, Koji Hashimoto, Machiko Tateishi, Ryuji Fukuhara, Mika Kitajima, Mamoru Hashimoto, Akihiko Kuniyasu, Toshinori Hirai, Manabu Ikeda, Yasuyuki Yamashita
Organizer
The 9th International Congress of the Asian Society Against Dementia
Place of Presentation
KKRホテル(熊本)
Year and Date
2015-09-14
Related Report
Int'l Joint Research
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[Presentation] Phase Difference Enhanced Imaging (PADRE) as Novel Non-invasive Tool for Amyloid Plaque Detection2015
Author(s)
Yoneda Tetsuya, Kurehana Nan, Hashimoto Koji, Tateishi Machiko, Fukuhara Ryuji, Kitajima Mika, Hashimoto Mamoru, Kuniyasu Akihiko, Hirai Toshinori, Ikeda Manabu, Yamashita Yasuyuki
Organizer
The 9th International Congress of the Asian Society Against Dementia
Place of Presentation
KKRホテル(熊本)
Year and Date
2015-09-14
Related Report
Int'l Joint Research
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[Presentation] Statistical Phase Noise Elimination for Amyloid Plaque Detection2015
Author(s)
Tetsuya Yoneda, Koji Hashimoto, Akihiko Kuniyasu, Toshinori Hirai, Mika Kitajima, Mamoru Hashimoto, Nan Kurehana, Michiya Iwata, Motohira Mio, Sosuke Yoshinaga, Hiroaki Terasawa, Manabu Ikeda, Yasuyuki Yamashita
Organizer
ISMRM 2015
Place of Presentation
Metro Toronto Convention Centere(トロント)
Year and Date
2015-05-30
Related Report
Int'l Joint Research
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