Dynamic image findings of digestion and absorption of fat: evaluating with MR imaging using elective inversion recovery pulse.

• Project/Area Number: 26461841
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kawasaki Medical School
• Principal Investigator: Yamamoto Akira 川崎医科大学, 医学部, 講師 (30319959)
• Co-Investigator(Kenkyū-buntansha): 伊東 克能 山口大学, 医学部附属病院, 教授 (00274168) ; 玉田 勉 川崎医科大学, 医学部, 准教授 (40278932)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 膵外分泌機能 / MRI / 脂肪吸収消化 / 脂肪吸収障害 / 腹部症状 / 脂肪便 / cine dynamic MRCP / pancreatic function / 機能的イメージング / MRイメージング / 脂肪消化吸収

Outline of Final Research Achievements

Flow of pancreatic juice from 5 to 19 min after ingestion were significantly higher than that before ingestion. Flow of pancreatic juice showed a maximum peak at 5 min after ingestion. Thereafter, the secretion grade of pancreatic juice tended to gradually decline.
Eighteen query-items in clinical questionnaire on abdominal symptoms was administered and compared to flow of pancreatic juice evaluating with MRI. Following query-items were significantly negative correlations with the secretion grades “Do your gas smell foul?” “Is stool quantity large?” “Is your stools soft?” These 3 symptoms are easily found in the patients of fat malabsorption. This MRI technique may contribute to diagnose at malabsorption.

Research Products

• [Journal Article] Age-related change of the secretory flow of pancreatic juice in the main pancreatic duct: evaluation with cine-dynamic MRCP using spatially selective inversion recovery pulse. (2014)
  • Author(s): Torigoe T, Ito K
  • Journal Title: AJR Am J Roentgenol Volume: 202 Issue: 5 Pages: 1022-1026
  • DOI: 10.2214/ajr.13.10852
  • Peer Reviewed
• [Journal Article] Assessment of physiologic bile flow in the extrahepatic bile duct with cine-dynamic MR cholangiopancreatography and a spatially selective inversion-recovery pulse. (2014)
  • Author(s): Ito K, Kanki A, Yamamoto A, Tamada T, Yasokawa K, Tanimoto D, Sato T, Higaki A, Noda Y, Yoshida K.
  • Journal Title: Radiology Volume: 270(3) Issue: 3 Pages: 777-783
  • DOI: 10.1148/radiol.13131046
  • Peer Reviewed
• [Presentation] Relationship Between Exocrine Pancreatic Function and Abdominal Symptoms: Evaluation Using Cine-Dynamic MRCP (2017)
  • Author(s): Akira Yamamoto, Katsuyoshi Ito, Teruki Sone, Kazuya Yasokawa, Hidemitsu Sotozono, Tomohiro Sato, Daigo Tanimoto, Minoru Hayashida, Tsutomu Tamada
  • Organizer: 日本医学放射線学会総会
• [Presentation] Assessment of prostate cancer detection and tumor aggressiveness using diffusion weighted and dynamic contrast-enhanced MR imaging at 3T (2017)
  • Author(s): Akira Yamamoto, Tsutomu Tamada, Katsuyoshi Ito
  • Organizer: European Society of Urogenital Radiology
  • Int'l Joint Research
• [Presentation] Image findings of the spleen: Spectrum of CT and MR imaging findings (2017)
  • Author(s): Akira Yamamoto, Tsutomu Tamada, Minoru Hayashida, Akihiko Kanki, Tomohiro Sato, Katsuyoshi Ito
  • Organizer: Radiological Society of North America
  • Int'l Joint Research
• [Presentation] Postprandial changes of secretory flow of pancreatic juice in the main pancreatic duct: Evaluation with cine dynamic MRCP and a spatially selective inversion recovery (IR) pulse (2015)
  • Author(s): Kazuya Yasokawa, Akira Yamamoto, Tsutomu Tamada, Akihiko Kanki, Atsushi Higaki, Yasufumi Noda, Katsuyoshi Ito
  • Organizer: ISMRM
  • Place of Presentation: Toronto CANADA
  • Year and Date: 2015-05-30
• [Presentation] Non-invasive investigation of exocrine pancreatic function using cine dynamic MRCP with a spatially selective IR pulse (2014)
  • Author(s): 八十川和哉、玉田 勉、山本 亮、神吉昭彦、檜垣 篤、鳥越晃之、野田靖文、伊東克能
  • Organizer: The 15th Asian Oceanian Congress of Radiology
  • Place of Presentation: Kobe Convention Center (Hyogo, Kobe)
  • Year and Date: 2014-09-24 – 2014-09-27
• [Presentation] Non-invasive investigation of exocrine pancreatic function using cine dynamic MRCP with a spatially selective IR pulse (2014)
  • Author(s): 八十川和哉、玉田 勉、山本 亮、神吉昭彦、檜垣 篤、野田靖文、木戸 歩、内野亜加音、外園英光、伊東克能
  • Organizer: 22rd International Society for Magnetic Resonance in Medicine (ISMRM)
  • Place of Presentation: MiCo-Milano Congressi (Italy, Milano)
  • Year and Date: 2014-05-10 – 2014-05-17
• [Presentation] Non-invasive investigation of exocrine pancreatic function using cine dynamic MRCP with a spatially selective IR pulse (2014)
  • Author(s): 八十川和哉、玉田 勉、山本 亮、神吉昭彦、檜垣 篤、野田靖文、伊東克能
  • Organizer: 第73回 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜 (神奈川県, 横浜市)
  • Year and Date: 2014-04-11 – 2014-04-13
• [Remarks] 川崎医科大学 放射線医学（画像診断１） ホームページ
  • URL: http://www.kawasaki-m.ac.jp/diag-radiology/